Low-methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healing

Basit Öğe Kaydı
dc.contributor.authorKocaaga B.
dc.contributor.authorKurkcuoglu O.
dc.contributor.authorTatlier M.
dc.contributor.authorBatirel S.
dc.contributor.authorGuner F.S.
dc.date.accessioned2024-07-12T21:50:10Z
dc.date.available2024-07-12T21:50:10Z
dc.date.issued2019en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThis study presents the design of novel hydrogel films, based on low-methoxyl (LM) pectin and NaA- or ZnA-zeolite particles, to serve as wound dressing materials with controlled drug delivery properties. We studied the effects of the preparation method of hydrogels, the amounts of crosslinker, drug and zeolite, and the type of cation in zeolites on the drug release mechanisms from the hydrogels. Ionic strengths of both film and external medium dictated the drug release behavior of the films, while the other parameters also played essential roles. NaA-zeolite hydrogels prepared using membrane diffusion controlled system, could reach a drug release ratio of 86% within 5 h. The drug-free hydrogels displayed no cytotoxicity while supporting cell proliferation and migration. Our cost-effective LM pectin–zeolite hydrogels promise to be effective wound dressing materials with controlled drug delivery ability, transparency, good swelling properties, ability to hold fluids, good oxygen transmission rate, and biocompatibility. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47640. © 2019 Wiley Periodicals, Inc.en_US
dc.description.sponsorshipThe authors sincerely thank Herbstrith & Fox Company (Germany) for providing LM pectin. This work was funded by The Scientific and Technological Research Council of Turkey (TUBITAK) with project number of 115M439.en_US
dc.identifier.doi10.1002/app.47640
dc.identifier.issn0021-8995
dc.identifier.issue24en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://dx.doi.org/10.1002/app.47640
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8137
dc.identifier.volume136en_US
dc.language.isoenen_US
dc.publisherJohn Wiley and Sons Inc.en_US
dc.relation.ispartofJournal of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01793
dc.subjectbiomedical applicationsen_US
dc.subjectbiopolymers and renewable polymersen_US
dc.subjectdrug delivery systemsen_US
dc.titleLow-methoxyl pectin–zeolite hydrogels controlling drug release promote in vitro wound healingen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu