The impact of intravenous lipid emulsion on lipophilicity in poisoned patients: A systematic review

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dc.authorid0000-0003-1996-7505en_US
dc.contributor.authorKarakılıç E.
dc.contributor.authorKaya E.
dc.contributor.authorErdem A.
dc.contributor.authorArslan E.D.
dc.contributor.authorDurdu T.
dc.contributor.authorTulgar S.
dc.contributor.authorIşcanlı D.
dc.date.accessioned2024-07-12T21:57:59Z
dc.date.available2024-07-12T21:57:59Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractObjective: Although the action mechanism of intravenous lipid emulsion has not been fully elucidated yet, its use in liposoluble drugs intoxications. In this study, we examined the lipophilic features of causative agents and the success of the treatment ILE therapy in intoxication cases. Methods: We reviewed 765 cases published in PubMed between 1966 and June, 2015. After applying exclusion criteria, totally 141 cases ingested single substance and received ILE therapy with 20% ILE solution were included in present study. Amount of lipid solutions given and the results were recorded. Success rate was statistically assessed according to log p values of the substances taken and the amount of lipid emulsion used. Results: 141 patients were involved in this study; log p values were calculated for all drugs regardless of the success of ILE therapy. ILE therapy under the amount of 100 ml failed to achieve successful outcome. ALOGPS and ChemAxon log P values were higher in cases, which received ILE therapy ? 500 ml and showed successful results. It was found that log p value had no contribution to the treatment success in the group received ILE therapy>500 ml. Conclusions: It was found that ILE therapy<500 ml was successful in drugs with higher lipophilicity while success rate was higher in ILE therapy>500 ml and that liposolubility had no significant contribution to treatment success. © 2017, Scientific Publishers of India. All rights reserved.en_US
dc.identifier.endpage7069en_US
dc.identifier.issn0970938X
dc.identifier.issue16en_US
dc.identifier.startpage7060en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8748
dc.identifier.volume28en_US
dc.language.isoenen_US
dc.publisherScientific Publishers of Indiaen_US
dc.relation.ispartofBiomedical Research (India)en_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY09262
dc.subjectIntravenous lipid emulsionen_US
dc.subjectLipophilicityen_US
dc.subjectPoisoningen_US
dc.titleThe impact of intravenous lipid emulsion on lipophilicity in poisoned patients: A systematic reviewen_US
dc.typeReview
dspace.entity.typePublication

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