Effects of Hyperandrogenism on Tear Function and Tear Drainage in Patients with Polycystic Ovary Syndrome
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Date
2011
Journal Title
Journal ISSN
Volume Title
Publisher
SCI PRINTERS & PUBL INC
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
OBJECTIVE: Polycys tic ovary syndrome (PCOS) is an endocrinopathy characterized by chronic anovulation and hyperandrogenism. Hormonal changes can affect ocular surface and tear functions. We evaluated dry eye symptoms, clinical tear film alterations, and tear clearance in patients with PCOS. STUDY DESIGN: Thirty-five women with PCOS and 22 healthy individuals were enrolled in the study. An ocular surface disease index (OSDI) questionnaire was administered, and after the routine ophthalmologic examination tear film breakup time (TB UT) and Schirmer tests were performed. Tear clearance was assessed via fluorescein dye disappearance test (FDDT). RESULTS: No difference was observed in Schirmer test between the groups, however OSDI scores were significantly higher (p=0.01) and TBUT was significantly lower (p=0.01) in PCOS patients than in the control women. FDDTs were not different between the PCOS and control subjects. CONCLUSION: Our findings suggest that patients diagnosed with PCOS should be advised to obtain an ophthalmic examination, especially for dry eye. (J Reprod Med 2011;56:65-70)
Description
Keywords
ocular surface disease index, polycystic ovary syndrome, Schirmer test, tear film breakup time, tears
Journal or Series
JOURNAL OF REPRODUCTIVE MEDICINE
WoS Q Value
Q4
Scopus Q Value
Q4
Volume
56
Issue
01.Feb
