Effects of fluvastatin treatment on insulin sensitivity in patients with hyperlipidaemia

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dc.authorid0000-0003-2045-1709en_US
dc.contributor.authorTop, C.
dc.contributor.authorTerekeci, Murat Hakan
dc.contributor.authorKeskin, O.
dc.contributor.authorÖnde, Mehmet Emin
dc.date.accessioned2024-07-12T21:04:41Z
dc.date.available2024-07-12T21:04:41Z
dc.date.issued2002en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThis study aimed to determine the effects of fluvastatin treatment on insulin sensitivity in patients with hyperlipidaemia. Non-obese, normoglycaemic, normotensive patients with hyperlipidaemia (n = 20) and a reference group of healthy subjects of similar age, sex, and body mass index (n = 20) were evaluated. Patients with other causes of peripheral insulin resistance were excluded. All participants underwent a diagnostic protocol, which included measurements of insulin sensitivity index and other metabolic parameters. Insulin sensitivity was assessed by Homeostasis Model Assessment (HOMA). Serum insulin levels were tested by radioimmunoassay. Patients were treated with fluvastatin 40 mg once daily for 3 months. Before fluvastatin treatment, fasting serum insulin levels were significantly raised in patients with hyperlipidaemia compared with subjects from the reference group (19.1 ± 13.4 versus 8.1 ± 3.4 ?lU/ml). The fasting serum insulin levels and HOMA-estimated insulin sensitivity were correlated in the whole group. Correlation analysis showed a significant relationship between HOMA-estimated insulin resistance and plasma cholesterol and triglyceride concentrations. Patients with hyperlipidaemia had reduced insulin sensitivity that was reflected by high serum fasting insulin levels. Anti-hyperlipidaemic treatment with fluvastatin increases insulin sensitivity.en_US
dc.identifier.citationCingözbay, B., Top, C., Terekeci, H., Keskin, Ö. ve Önde, M. (2002). Effects of Fluvastatin Treatment on Insulin Sensitivity in Patients with Hyperlipidaemia. Journal of International Medical Research, Sage Journals. s. 21–25.en_US
dc.identifier.endpage25en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage21en_US
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/147323000203000104?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3818
dc.institutionauthorCingözbay, Bekir Yılmaz
dc.language.isoenen_US
dc.publisherSage Journalsen_US
dc.relation.ispartofJournal of International Medical Researchen_US
dc.relation.isversionof10.1177/147323000203000104en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY01933
dc.subjectFluvastatinen_US
dc.subjectStatinen_US
dc.subjectHyperlipidaemiaen_US
dc.subjectInsulin sensitivityen_US
dc.titleEffects of fluvastatin treatment on insulin sensitivity in patients with hyperlipidaemiaen_US
dc.typeArticle
dspace.entity.typePublication

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