Predicting the probability of meningioma recurrence in the preoperative and early postoperative period: a multivariate analysis in the midterm follow-up

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dc.authorid0000-0002-8335-1927en_US
dc.contributor.authorİldan, Faruk
dc.contributor.authorErman, Tahsin
dc.contributor.authorGöçer, İskender
dc.contributor.authorTuna, Metin
dc.contributor.authorBağdatoğlu, Hüseyin
dc.contributor.authorÇetinalp, Erdal
dc.contributor.authorBurgut, Hüseyin Refik
dc.date.accessioned2024-07-12T21:11:07Z
dc.date.available2024-07-12T21:11:07Z
dc.date.issued2007en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractWe reviewed the clinical, radiological, surgical, and histopathological features of patients with meningiomas to identify factors that can predict tumor recurrence after ‘‘microscopic total removal,’’ to improve preoperative surgical planning, and to help determine the need for close radiological observation at shorter intervals or the need for radiotherapy as an adjuvant treatment in the early postoperative period. Clinical data, magnetic resonance imaging studies, angiographic data, operative reports, and histopathological findings were examined retrospectively in 137 patients with a meningioma treated microsurgically and with no evidence of residual tumor on postoperative MR images. Based on univariate analysis, tumor size, a mushroom shape, proximity to major sinuses, edema, osteolysis, cortical penetration, signal intensity on T2-weighted MRIs, pial-cortical arterial supply, presence of a brain-tumor interface in surgery, Simpson’s criteria, and histopathological classification were significant predictors for recurrence. However, age, gender, location of tumor, dural tail, calcification, signal intensity on T1-weighted images, and histopathologic subtypes in the benign group were not significant predictors. By Cox regression analysis the most important variables related to the time to recurrence were mushroom shape, osteolysis, dural tail, and proximity to major sinuses. Aggressive surgical therapy with wider dural removal should be considered in the presence of the preoperative predictors of a recurrence. Close radiological observation at shorter intervals or radiotherapy should be considered as adjuvant therapy in high-risk patients based on surgical findings predicting recurrence related to the brain-tumor interface, Simpson’s criteria, and histopathological findings in the early postoperative period.en_US
dc.identifier.citationİldan, F., Erman, T., Göçer, A. İ., Tuna, M., Bağdatoğlu, H., Çetinalp, E. ve Burgut, H. R. (2007). Predicting the probability of meningioma recurrence in the preoperative and early postoperative period: A multivariate analysis in the midterm followup. Skull Basean Interdisciplinary Approach. 17(3), s. 157-171.en_US
dc.identifier.endpage171en_US
dc.identifier.issue3en_US
dc.identifier.startpage157en_US
dc.identifier.urihttps://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2007-970554
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4336
dc.identifier.volume17en_US
dc.institutionauthorBurgut, Hüseyin Refik
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag KGen_US
dc.relation.ispartofSkull Basean Interdisciplinary Approachen_US
dc.relation.isversionof10.1055/s2007970554en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY03420
dc.subjectAngiographyen_US
dc.subjectMagnetic resonance imagingen_US
dc.subjectMeningiomaen_US
dc.subjectTumor recurrenceen_US
dc.titlePredicting the probability of meningioma recurrence in the preoperative and early postoperative period: a multivariate analysis in the midterm follow-upen_US
dc.typeArticle
dspace.entity.typePublication

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