Increased P wave dispersion in patients with liver steatosis

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dc.authorid0000-0002-5634-1280en_US
dc.authorid0000-0003-1407-5313en_US
dc.authorid0000-0002-2858-4023en_US
dc.authorid0000-0001-7261-2397en_US
dc.contributor.authorAparcı, Mustafa
dc.contributor.authorIşılak, Zafer
dc.contributor.authorUz, Ömer
dc.contributor.authorKardeşoğlu, Ejder
dc.contributor.authorYiğiner, Ömer
dc.contributor.authorSıldıroğlu, Onur Hüseyin
dc.contributor.authorYalçın, Murat
dc.contributor.authorÖzmen, Namık
dc.contributor.authorCebeci, Bekir Sıtkı
dc.date.accessioned2024-07-12T21:10:10Z
dc.date.available2024-07-12T21:10:10Z
dc.date.issued2010en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractAim: Hepatic steatosis is associated with metabolic and hemodynamic abnormalities induced by insulin resistance and inflammatory state. Since abnormalities of P wave dispersion may be accompanied with latter issues we evaluated this subject in patients with hepatic steatosis. Methods: Total of 106 patients and 56 healthy subjects were enrolled and performed hepatic ultrasonography, echocardiography, electrocardiogram, and biochemistry tests. Clinical features, laboratory and echocardiographic parameters, P wave dispersion were compared between groups and analyzed for any correlation among parameters. Results: Body mass index (BMI), waist circumference, systolic and diastolic blood pressure, levels of total and LDL cholesterol, and fasting blood glucose (FBG), and left atrial diameter were significantly higher in patients with hepatic steatosis. Peak velocities of mitral E and A waves and their ratio were abnormally changed in patients compared to normals. In multiple linear regression analysis, approximately all of the variables previously correlated within Pearsons' correlation test were found to be significantly correlated with P wave dispersion [ waist circumference (ß=0.151, p=0.048), LDL cholesterol (ß=0.234, p=0.000), FBG (ß=0.402, p= 0.000), alanine aminotransferase (ALT) (ß=0.205, p= 0.006), alkaline phosphatase (ALP) (ß=0.277, p=0.000), ?-glutamyl transferase (?-GT) (ß=0.240, p=0.000), left atrial diameter (ß=0.204, p=0.003), heart rate (ß=0.123, p=0.037)]. Conclusions: Increased P wave dispersion may indicate a risk of atrial arrhythmia which may be complicated with disabling symptoms and thromboembolism in patients with hepatic steatosis. Consequently, hepatic steatosis is associated with increased risk for cardiovascular disease due to metabolic and hemodynamic abnormalities probably induced by insulin resistance and inflammaory state.en_US
dc.identifier.citationAparci, M., Isilak, Z., Uz, O., Kardesoglu, E., Yiginer, O., Sildiroglu, O., Yalcin, M., Ozmen, N., Cingozbay, B. Y. ve Cebeci, B. S. (2010). Increased P wave dispersion in patients with liver steatosis. Medicinski glasnik, DOAJ. 7(2), s. 143–147.en_US
dc.identifier.endpage147en_US
dc.identifier.issn1840-0132
dc.identifier.issn1840-2445
dc.identifier.issue2en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage143en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/21258310/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4199
dc.identifier.volume7en_US
dc.institutionauthorCingözbay, Bekir Yılmaz
dc.language.isoenen_US
dc.publisherDOAJen_US
dc.relation.ispartofMedicinski Glasniken_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY02902
dc.titleIncreased P wave dispersion in patients with liver steatosisen_US
dc.typeArticle
dspace.entity.typePublication

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