Effect of escitalopram alone or combination wıth sorafenib on hepg2 hepatocellular cell line proliferation

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dc.authorid0000-0002-3060-1507en_US
dc.authorid0000-0002-4605-1167en_US
dc.authorid0000-0002-4474-7371en_US
dc.date.accessioned2024-07-12T21:11:02Z
dc.date.available2024-07-12T21:11:02Z
dc.date.issued2020en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractHepatocellular carcinoma is one of the most common cancers. The main treatment for hepatocellular cancers is surgery. Drug treatment can be performed in advanced cases after surgical treatment or relapse therapy. Sorafenib is a drug that is used primarily in the treatment of hepatocellular cancer. Escitalopram is a drug in the serotonin reuptake inhibitor group used to treat depression. There are studies showing the effect of escitalopram on proliferation. The purpose of this study is to evaluate the use of escitalopram alone and in combination with sorafenib in liver cancer. The effect of escitalopram and in combination on proliferation of hepatocellular cell lines was assessed by xtt proliferation assay. The half inhibiting concentration (ic 50) was calculated by regression analysis, photographed under an inverted microscope. The synergistic effect has been evaluated. The effect on morphological changes was visualized under the inverted microscope. The results of our study confirm the synergistic effect of use of escitalopram in combination with sorafenib in liver cancer. Prospective randomized trials are needed to evaluate its clinical use.en_US
dc.identifier.citationÖzünal, Z. G., Dönmez Çakıl, Y., Sağlam, E. ve Aktaş, R. G. (2020). Effect of escitalopram alone or combination wıth sorafenib on hepg2 hepatocellular cell line proliferation. Research and Science Today, RST Journal. 1(19), s. 201-210.en_US
dc.identifier.endpage210en_US
dc.identifier.issn2247-4455
dc.identifier.issn2285-9632
dc.identifier.issue19en_US
dc.identifier.startpage201en_US
dc.identifier.urihttps://www.rstjournal.com/mdocs-posts/20-zeynep-gunes-ozunal-yaprak-donmez-cakil-esra-saglam-et-all-effect-of-escitalopram-alone-or-combination-with-sorafenib-on-hepg2-hepatocellular-cell-line-proliferation/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4318
dc.identifier.volume1en_US
dc.institutionauthorÖzünal, Zeynep Güneş
dc.institutionauthorDönmez Çakıl, Yaprak
dc.institutionauthorSağlam, Esra
dc.institutionauthorAktaş, Ranan Gülhan
dc.language.isofren_US
dc.publisherRST Journalen_US
dc.relation.ispartofResearch and Science Todayen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.snmzKY03342
dc.subjectEscitalopramen_US
dc.subjecthepg2en_US
dc.subjectproliferationen_US
dc.subjectsorafeniben_US
dc.subjectcanceren_US
dc.titleEffect of escitalopram alone or combination wıth sorafenib on hepg2 hepatocellular cell line proliferationen_US
dc.typeArticle
dspace.entity.typePublication

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