Serum and follicular fluid levels of soluble Fas and soluble Fas ligand in IVF cycles

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dc.authorid0000-0003-3446-3751en_US
dc.authorid0000-0002-0717-1756en_US
dc.authorid0000-0003-4563-3592en_US
dc.contributor.authorÖnalan, Göğşen
dc.contributor.authorSelam, Belgin
dc.contributor.authorÖnalan, Reşide
dc.contributor.authorCeyhan, Temel
dc.contributor.authorPabuçcu, Recai
dc.date.accessioned2024-07-12T21:03:40Z
dc.date.available2024-07-12T21:03:40Z
dc.date.issued2006en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective To determine follicular fluid (FF) and serum levels of soluble Fas (sFas) and soluble Fas ligand (sFasL) in patients undergoing IVF cycles. Study Design A prospective comparative study among patients with endometriosis (n = 12), infertility due to male factor (n = 12) and poor responders (n = 32) undergoing IVF cycles in Centrum IVF Clinic. Individual FF and serum samples were collected from patients during transvaginal ultrasonography-guided follicle aspiration. Patients were classified as poor responder patients undergoing IVF cycles with GnRHa, triptorelin and GnRH antagonist, cetrotide, patients with endometriosis and patients with infertility due to male factor. sFas, sFasL levels in both FF and serum samples and their correlations with clinical outcomes of IVF were measured in each study group. Results Serum and FF levels of sFas, sFasL were similar in the poor responder and male factor groups. There were no differences between the serum and FF levels of both sFas and sFasL among poor responder patients receiving either GnRH agonist or antagonist therapies. Serum levels of sFas were significantly lower in the endometriosis group compared to the male factor group. Serum and FF levels of sFas, sFasL were similar among patients with or without clinical pregnancy. Conclusion sFas and sFasL are detected in both serum and follicular fluid samples from IVF cycles, their levels are similar between poor responder and male factor groups as well as between GnRH agonist and antagonist treatment groups. These soluble apoptotic factors may not be predictive for the outcomes of IVF. Decreased serum levels of sFas, suggests increased apoptosis in endometriosis.en_US
dc.identifier.citationOnalan, G., Selam, B., Onalan, R., Ceyhan, T., Cincik, M. ve Pabuccu, R. (2006). Serum and follicular fluid levels of soluble Fas and soluble Fas ligand in IVF cycles. European journal of obstetrics, gynecology, and reproductive biology, Elsevier. 125(1), s. 85–91.en_US
dc.identifier.endpage91en_US
dc.identifier.issn0301-2115
dc.identifier.issn1872-7654
dc.identifier.issue1en_US
dc.identifier.startpage85en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0301211505004185?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3688
dc.identifier.volume125en_US
dc.institutionauthorCıncık, Mehmet
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofEuropean Journal of Obstetrics & Gynecology and Reproductive Biologyen_US
dc.relation.isversionof10.1016/j.ejogrb.2005.08.002en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY00863
dc.subjectsFasen_US
dc.subjectsFasLen_US
dc.subjectFollicular fluiden_US
dc.subjectSerumen_US
dc.subjectIVFen_US
dc.subjectPoor responderen_US
dc.titleSerum and follicular fluid levels of soluble Fas and soluble Fas ligand in IVF cyclesen_US
dc.typeArticle
dspace.entity.typePublication

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