The effect of electrophysiological and neuroimaging findings on the prognosis of juvenile myoclonic epilepsy proband

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dc.authorid0000-0002-3868-9814en_US
dc.authorid0000-0002-8335-1927en_US
dc.contributor.authorAslan, Kezban
dc.contributor.authorBozdemir, Hacer
dc.contributor.authorYapar, Zeynep
dc.contributor.authorBurgut, Hüseyin Refik
dc.date.accessioned2024-07-12T21:10:23Z
dc.date.available2024-07-12T21:10:23Z
dc.date.issued2013en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground: Juvenile myoclonic epilepsy (JME) is a well-defined idiopathic generalized epileptic syndrome, and diagnostic criteria for JME are to have a normal brain imaging and clinical evidence of typical epileptic seizures. The aim of this study is to evaluate electrophysiological and neuroimaging findings of JME and determine their relationship with prognosis. Methods: Thirty-two patients (23 women and nine men) with a mean age of 22 (16–37) years were included in this study. Interictal electroencephalography (EEG), magnetic resonance imaging (MRI) and single photon emission computed tomography (SPECT) were carried out in all patients. Results: Analysis of premedication EEGs revealed primary generalized pattern activity in 75% (n524) and focal abnormalities in 18. 75% (n56). MRI was abnormal in seven (21. 88%) patients (two with arachnoid cyst, two with mild cerebral atrophy, two with ventricular enlargement and one with single gliotic lesion), and SPECT imaging detected hypoperfusion in 15 (47%) patients. Hypoperfusion was mostly found on the parietal lobe. Conclusion: We found that, after medication, only 6. 25% of EEGs had primary generalized pattern activity (p,0. 0001); nevertheless, the prognosis was good in patients who had typical EEG findings (p50. 106). The prognosis of patients with MRI abnormalities was grave (p50. 023). Twenty percent of the patients who had SPECT abnormalities were seizure free, and 80% of them had been partially controlled (p50. 059). There were no correlations between MRI abnormalities, EEG and SPECT findings.en_US
dc.identifier.citationAslan, K., Bozdemir,., Yapar, Z. ve Burgut, H. R. (2013). The effect of electrophysiological and neuroimaging findings on the prognosis of juvenile myoclonic epilepsy proband. 32(6), s. 620-624.en_US
dc.identifier.endpage624en_US
dc.identifier.issn1743-1328
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage620en_US
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1179/174313209X455727
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4245
dc.identifier.volume32en_US
dc.institutionauthorBurgut, Hüseyin Refik
dc.language.isoenen_US
dc.publisherTaylor and Francis Onlineen_US
dc.relation.ispartofNeurological Researchen_US
dc.relation.isversionof10.1179/174313209X455727en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03100
dc.subjectJuvenile myoclonic epilepsyen_US
dc.subjectEEGen_US
dc.subjectSPECTen_US
dc.subjectMRIen_US
dc.subjectPrognosisen_US
dc.titleThe effect of electrophysiological and neuroimaging findings on the prognosis of juvenile myoclonic epilepsy probanden_US
dc.typeArticle
dspace.entity.typePublication

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