Use of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: A comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy

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dc.authorid0000-0002-3233-8263en_US
dc.authorid0000-0003-2465-9128en_US
dc.authorid0000-0002-4474-7371en_US
dc.contributor.authorDurmuş-Altun, Gülay
dc.contributor.authorAltun, Armağan
dc.contributor.authorSalihoğlu, Yavuz sami
dc.contributor.authorYiğitbaşı, Necmi Ömer
dc.date.accessioned2024-07-12T21:01:43Z
dc.date.available2024-07-12T21:01:43Z
dc.date.issued2005en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractThe purpose of the study was; (i) to determine whether123I-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with99mTc-DTPA radioaerosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 ± 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent123I-MIBG and99mTc-DTPA radioaerosol scintigraphy at the end of the treatment period.123I-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after intravenous injection of the radiopharmaceutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of123I-MIBG were determined. Two days after123I-MIBG scintigraphy,99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation.123I-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 ± 4.6 vs. 40 ± 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T1/2 values of DTPA clearance were significantly increased in AIPT group according to the control group (55 ± 7.2 vs. 86.6 ± 18.5, p = 0.02).123I-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally,99mTc-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost.en_US
dc.identifier.citationDurmuş-Altun, G., Altun, A., Aktas, R.G. et al. (2005). Use of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: A comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy. Annals of Nuclear Medicine, Springerlink. 19(3), s. 217-224.en_US
dc.identifier.endpage224en_US
dc.identifier.issn1864-6433
dc.identifier.issn0914-7187
dc.identifier.issue3en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage217en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/BF02984608#citeas
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3528
dc.identifier.volume19en_US
dc.institutionauthorAktas, Ranan Gulhan
dc.language.isoenen_US
dc.publisherSpringerlinken_US
dc.relation.ispartofAnnals of Nuclear Medicineen_US
dc.relation.isversionof10.1007/BF02984608en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY00263
dc.subjectamiodaroneen_US
dc.subjectpulmonary toxicityen_US
dc.subject123I-MIBGen_US
dc.subject99mTc-DTPA radioaerosolen_US
dc.subjectscintigraphyen_US
dc.titleUse of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: A comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphyen_US
dc.typeArticle
dspace.entity.typePublication

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