Galactose-induced aging model in rat testicular tissue

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dc.authorid0000-0001-5114-8660en_US
dc.contributor.authorAydın, Şeval
dc.contributor.authorYanar, Karolin
dc.contributor.authorŞimşek, Bahadır
dc.contributor.authorCebe, Tamer
dc.contributor.authorSitar, Mustafa Erinç
dc.contributor.authorBelce, Ahmet
dc.contributor.authorÇakatay, Ufuk
dc.date.accessioned2024-07-12T21:04:39Z
dc.date.available2024-07-12T21:04:39Z
dc.date.issued2018en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjective: To examine whether the D-galactose induced aging model is an appropriate model for further aging research. Study Design: Experimental study. Place and Duration of Study: Aziz Sancar Institute of Experimental Medicine, Istanbul University, Turkey, June 2015- June 2017. Methodology: The study comprises 3 groups of rats. Group I is young control (YC) 5-month-old rats. Group II is 5-monthold rats, which were mimetically aged (MA) for 6 weeks via intraperitoneal D-galactose (60 mg/kg body weight/day, 0.5 mL) administration. Group III is naturally aged (NA) 24-month-old rats. Group I and III received intraperitoneal saline (0.9% 0.5 mL) for 6 weeks as vehicle. Group I and Group II received injections at 21 weeks age and Group III rats 6 weeks before 24 months age. Tissues were harvested when rats became 6.5-month-old (Group I and Group II) and 24-month-old (Group III). Quantitative biochemical analyses of proteins, lipids, DNA biomarkers and Cu, Zn-SOD were conducted. Statistical analysis of the data was conducted using ANOVA, followed by post-hoc Bonferroni test. Results: Higher magnitude of oxidative damage and diminished antioxidant defence capacity were found in both mimetically aged and naturally aged testicular tissues. It is observed that D-galactose aging model group shares significant similarities in terms of impaired redox homeostasis with the naturally aged rats. Conclusion: D-galactose induced testicular aging model successfully mimics aging process. Therefore, D-galactose induced aging model may be used as an accelerated aging model to study the age related alterations and interventions.en_US
dc.identifier.citationAydın, Ş., Yanar, K., Şimşek, B. vd. (2018). Galactose-induced aging model in rat testicular tissue. Journal of College of Physicians and Surgeons Pakistan, College of Physicians & Surgeons. 28(7), s. 501-504.en_US
dc.identifier.endpage504en_US
dc.identifier.issn1681-7168
dc.identifier.issue7en_US
dc.identifier.startpage501en_US
dc.identifier.urihttps://jcpsp.pk/archive-detail.php
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3808
dc.identifier.volume28en_US
dc.institutionauthorSitar, Mustafa Erinç
dc.language.isoenen_US
dc.publisherCollege of Physicians & Surgeonsen_US
dc.relation.ispartofJournal of College of Physicians and Surgeons Pakistanen_US
dc.relation.isversionof10.29271/jcpsp.2018.07.501en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01860
dc.subjectGalactoseen_US
dc.subjectNatural agingen_US
dc.subjectMimetic agingen_US
dc.subjectOxidative stressen_US
dc.subjectRedox homeostasisen_US
dc.subjectTestisen_US
dc.titleGalactose-induced aging model in rat testicular tissueen_US
dc.typeArticle
dspace.entity.typePublication

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