Relationship between echocardiographically evaluated aortic stiffness and prolidase activity in aortic tissue of patients with critical coronary artery disease

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dc.authorid0000-0001-7914-2201en_US
dc.contributor.authorKoçarslan, Aydemir
dc.contributor.authorKoçarslan, Sezen
dc.contributor.authorAydın, Mehmet Salih
dc.contributor.authorAltıparmak, İbrahim Halil
dc.contributor.authorDemir, Deniz
dc.contributor.authorSezen, Hatice
dc.contributor.authorYüce, Hasan Hüsnü
dc.contributor.authorGöz, Mustafa
dc.contributor.authorDemir, Deniz
dc.date.accessioned2024-07-12T21:00:29Z
dc.date.available2024-07-12T21:00:29Z
dc.date.issued2016en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground and Aims The aim of this study was to determine the relationship between echocardiographically evaluated aortic stiffness and prolidase activity in aortic tissue of patients with critical coronary occlusion. Methods Thirty six patients with coronary artery disease (CAD) scheduled for CABG and 30 control patients with no CAD proven angiographically were enrolled in this study. Plasma prolidase activities were quantified spectrophotometrically. During performance of the proximal anastomoses in the study group, a piece of aortic tissue was taken by punch and tissue prolidase activity was quantified spectrophotometrically and also evaluated pathologically by prolidase immunostaining. Eventually, the correlation of plasma prolidase activity, aortic tissue prolidase activity and aortic prolidase immunohistochemical staining with aortic stiffness was studied. Results The correlation of aortic stiffness with aortic tissue prolidase activity (rs = 0.364; p = 0.029) and aortic prolidase immunohistochemical staining (rs = 0.354; p = 0.034) was significant in the study group. However, the correlation of plasma prolidase activity with aortic stiffness was not statistically significant (rs = 0.083; p = 0.292). Linear regression analysis showed that the aortic stiffness ? index was significantly associated with aortic tissue prolidase activity (? = 0.354; p = 0.034) and statin usage (? = ?0.334; 0.047) in the study group. Regression analysis revealed that ATPA and statin use were predictors of aortic stiffness, and API+ was found to be the predictor for ATPA (? = 0.449; p = 0.006). Conclusion Aortic tissue prolidase activity was more significant than plasma prolidase activity and aortic tissue prolidase immunohistochemical staining in the relationship with aortic stiffness in the critical CAD group.en_US
dc.identifier.citationKoçarslan, A. and et al. (2016). Relationship between echocardiographically evaluated aortic stiffness and prolidase activity in aortic tissue of patients with critical coronary artery disease. Archives of Medical Research, Elsevier. 47(3), s. 200-206.en_US
dc.identifier.endpage206en_US
dc.identifier.issn1873-5487
dc.identifier.issue3en_US
dc.identifier.startpage200en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0188440916300662?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3385
dc.identifier.volume47en_US
dc.institutionauthorDemir, Deniz
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.relation.isversionof10.1016/j.arcmed.2016.06.009en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00341
dc.subjectAortic stiffnessen_US
dc.subjectBlood prolidaseen_US
dc.subjectTissue prolidaseen_US
dc.subjectImmunohistochemistryen_US
dc.subjectCoronary artery diseaseen_US
dc.titleRelationship between echocardiographically evaluated aortic stiffness and prolidase activity in aortic tissue of patients with critical coronary artery diseaseen_US
dc.typeArticle
dspace.entity.typePublication

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