The value of pleural fluid anti-A60 IgM in BCG-vaccinated tuberculous pleurisy patients

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dc.authorid0000-0002-4075-6692en_US
dc.contributor.authorKunter, E.
dc.contributor.authorCerrahoğlu, K.
dc.contributor.authorİlvan, A.
dc.contributor.authorIşıtmangil, T.
dc.contributor.authorOkutan, O.
dc.contributor.authorKartaloğlu, Z.
dc.contributor.authorÇavuşlu, S.
dc.date.accessioned2024-07-12T21:03:02Z
dc.date.available2024-07-12T21:03:02Z
dc.date.issued2003en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractObjectives To determine if detection of IgM and IgG antibodies against mycobacterial antigen A60, together with the Mantoux tuberculin skin test (TST), could be used in the diagnosis of tuberculous pleurisy (TP) in BCG-vaccinated cases. Methods We investigated 125 BCG-vaccinated patients with pleural effusion. Of these, 88 had TP and 37 had non-tuberculous pleurisy (NTP). TST and anti-A60 IgM and IgG measurements by ELISA were performed in the sera and pleural effusions of both groups. Results Cut-off values, in optical density, for serum anti-A60 IgM, pleural fluid anti-A60 IgM, serum anti-A60 IgG and pleural fluid anti-A60 IgG were defined as 0.624, 0.614, 0.464, and 0.613, respectively. TP patients had higher IgG and IgM levels in the serum (P < 0.001 and P < 0.05, respectively) and pleural effusion (P < 0.001 and P < 0.001, respectively). Regardless of the diagnosis, IgG and IgM levels were higher in the sera (P < 0.001 and P < 0.05, respectively) and pleural effusions (P < 0.001 and P < 0.001, respectively) of TST-positive cases, and serum and pleural fluid IgM levels were higher (P < 0.001 and P < 0.001, respectively) in the TST-positive TP cases. Sensitivity and specificity of TST were 65% and 68%, respectively. As a single parameter, pleural fluid anti-A60 IgM had the highest sensitivity (77%) and specificity (94%) in patients with negative TST. Conclusion We suggest that in populations where tuberculosis prevalence is high and BCG vaccination is common, pleural fluid anti-A60 IgM can facilitate the diagnosis of TP.en_US
dc.identifier.endpage220en_US
dc.identifier.issn1470-9465
dc.identifier.issue3en_US
dc.identifier.startpage212en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1198743X14624691?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3619
dc.identifier.volume9en_US
dc.institutionauthorTürken, Orhan
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofClinical Microbiology and Infectionen_US
dc.relation.isversionof10.1046/j.1469-0691.2003.00536.xen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsCC0 1.0 Universal*
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/*
dc.snmzKY00534
dc.subjectTuberculous pleurisyen_US
dc.subjectserologyen_US
dc.subjectMantoux testen_US
dc.subjectBCG vaccinationen_US
dc.titleThe value of pleural fluid anti-A60 IgM in BCG-vaccinated tuberculous pleurisy patientsen_US
dc.typeArticle
dspace.entity.typePublication

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