Romatoid artritli hastalarda serum interleukin 1? düzeyleri ile insülin direnci arasındaki ilişki
Küçük Resim Yok
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Uludağ Üniversitesi Tıp Fakültesi
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Dolaşımdaki normal düzeylerde insüline hedef hücrenin cevabında bozulma olarak tanımlanan insülin direnci, sık rastlanan patolojik bir durumdur. Sitokinlerin insülin duyarlılığı üzerindeki potansiyel etkileri yoğun araştırmalara konu olmuştur. Bu çalışmanın amacı, romatoid artritli hastalarda insülin direnci gibi glukoz metabolizma anormallikleri ile serum interleukin 1? düzeyleri arasındaki bağlantıyı araştırmaktır. Çalışmaya değişik derecelerde hastalık aktivitesine sahip romatoid artritli 36 hasta (22 kadın ve 14 erkek, ortalama yaş: 51.5 ±17.1 yıl (21-80 yaş arası), ortalama VKİ: 27.1±5.0 kg/m²) ve yaş, cinsiyet, VKİ olarak benzer özelliklere sahip 20 sağlıklı kontrol dahil edilmiştir. Açlık serum IL-1? ve insülin düzeyleri ölçüldü. İnsülin duyarlılığı HOMA yöntemiyle hesaplandı. Romatoid artritli hastalarda kontrollere oranla açlık serum insülin düzeyleri, HOMA skorları ve serum IL-1? düzeyleri anlamlı derecede yüksekti (14.7±6.7, 8.7±1.9 µIU/ml, p
Insulin resistance is a common pathological state in which target cells fail to respond to ordinary levels of circulating insulin. The cytokines are the subject of intense research for potential effects on insulin sensitivity. The aim of our study was to evaluate the correlation of the changes in serum IL-1? levels with glucose metabolism abnormality, such as insulin resistance, in patients with rheumatoid arthritis. In this study, 36 subjects (22 women and 14 men, aged 51.5 ±17.1 years, ranging between 21-80, BMI 27.1±5.0 kg/m²) with varying degrees of disease activity and a control group of 20 healthy subjects matched by age, sex, and body mass index were evaluated. The fasting serum IL-1? and insulin levels were measured. HOMA–estimated insulin sensitivity was calculated. The fasting insulin levels, HOMA scores and serum IL-1? levels were significantly higher in all patients with rheumatoid artritis than in control subjects (14.7±6.7 vs. 8.7±1.9 µIU/ml, p<0.001 and 3.3±1.5 vs. 1.9±0.5, p<0.001 and 18.2±13.3 vs. 13.0±2.4 pg/ml, p<0.01 respectively). A correlation was found between the fasting insulin, HOMA-IR and IL-1? in the whole group. In our study, we showed that patients with rheumatoid arthritis have an altered IL-1? regulation, and there was a significant correlation between serum IL-1? levels and insülin sensitivity in patients with rheumatoid arthritis.
Insulin resistance is a common pathological state in which target cells fail to respond to ordinary levels of circulating insulin. The cytokines are the subject of intense research for potential effects on insulin sensitivity. The aim of our study was to evaluate the correlation of the changes in serum IL-1? levels with glucose metabolism abnormality, such as insulin resistance, in patients with rheumatoid arthritis. In this study, 36 subjects (22 women and 14 men, aged 51.5 ±17.1 years, ranging between 21-80, BMI 27.1±5.0 kg/m²) with varying degrees of disease activity and a control group of 20 healthy subjects matched by age, sex, and body mass index were evaluated. The fasting serum IL-1? and insulin levels were measured. HOMA–estimated insulin sensitivity was calculated. The fasting insulin levels, HOMA scores and serum IL-1? levels were significantly higher in all patients with rheumatoid artritis than in control subjects (14.7±6.7 vs. 8.7±1.9 µIU/ml, p<0.001 and 3.3±1.5 vs. 1.9±0.5, p<0.001 and 18.2±13.3 vs. 13.0±2.4 pg/ml, p<0.01 respectively). A correlation was found between the fasting insulin, HOMA-IR and IL-1? in the whole group. In our study, we showed that patients with rheumatoid arthritis have an altered IL-1? regulation, and there was a significant correlation between serum IL-1? levels and insülin sensitivity in patients with rheumatoid arthritis.
Açıklama
Anahtar Kelimeler
Romatoid Artrit, İnsülin Direnci, İnterleukin 1?, Rheumatoid Arthritis, Insulin Resistance, Interleukin 1?
Kaynak
Uludağ Üniversitesi Tıp Fakültesi Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
28
Sayı
3
Künye
Top, C., Cingözbay, B. Y, Keskin, Ö., Tuncel, A. ve Önde, M. E. (2002). Romatoid artritli hastalarda serum interleukin 1? düzeyleri ile insülin direnci arasındaki ilişki / The serum interleukin 1? levels in patients with rheumatoid arthritis and correlation with insulin resistance. Uludağ Üniversitesi Tıp Fakültesi Dergisi, Uludağ Üniversitesi Tıp Fakültesi. 28(3), s. 81-84.
