Hipertansif hastalarda sol ventrikül hipertrofisi gelişmesine leptin düzeylerinin etkisi
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Nobel İlaç San. ve Tic A.Ş.
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Amaç: Leptin, yağ dokusunda sentez edilen ve başta sempatik sinir sistemi aktivasyonu olmak üzere birçok sisteme etkisi olan bir hormondur. Hipertansif hastalarda leptin düzeylerinin yüksek olduğu bilinmektedir. Amacımız, hipertansif hastalarda sol ventrikül hipertrofisi (SVH) gelişmesinde leptin düzeylerinin etkisi olup olmadığını belirlemektir. Materyal ve Metot: Çalışmaya hipertansif 40 hasta alındı. Hastalar, ekokardiyografik olarak belirlenen sol ventrikül kitle ve kitle indeksine göre iki gruba ayrıldı. Birinci grup, SVH olan 27 hasta (18?i kadın, 9?u erkek ve yaş ortalaması 59,1±7,2 yıl) ve 2. grup ise SVH olmayan 13 hastadan (5?i kadın, 8?i erkek ve yaş ortalaması 62,4±4,9 yıl) oluşturuldu. Hastalardan, ayrıntılı ekokardiyografi incelemesinden sonra, aç durumda kan alındı. Serumları çalışma zamanına kadar -80 0C derin dondurucuda saklandı. Plazma leptin düzeyleri, ?ELİSA? yöntemi kullanılarak belirlendi. İki grubun klinik, ekokardiyografik parametreleri ve plazma leptin düzeyleri karşılaştırıldı. Bulgular: İki grup arasında kullanılan ilaçlar, hipertansiyon süresi, vücut kitle indeksi bakımından anlamlı fark tespit edilmedi. Birinci grubun plazma leptin düzey ortalaması 33,3 ± 15,3 ngr/ml iken, 2. grupta bu değer, 28,3 ± 17,6 ngr/ml şeklindeydi. İki değer karşılaştırıldığında istatistiksel olarak anlamlı fark tespit edilmedi (p>0,05). Sonuç: Sonuç olarak, SVH mevcut olan hipertansif hastalarda leptin düzeyi SVH olmayan hipertansif hastalardan farklı değildir. Bu sonuç, leptinin hipertansif hastalarda SVH gelişmesinde belirgin rolünün olmadığını düşündürmektedir.
Aims: Leptin, which is a hormone secreted by adipose tissue, has many effects on the sympathetic nervous system and other systems. It is well-known that hypertension is associated with high leptin levels. The aim of this study was to determine whether there is any effect of leptin on the development of left ventricular hypertrophy(LVH) in hypertensive patients. Material and methods: Forty hypertensive patients were enrolled to the study. The study population was divided into two groups according to LVH determined by echocardiography. Group 1 was consisted of 27 hypertensive patients with LVH(m/f: 9/18, the mean age:59.1±7.2yrs) while group 2 was composed of 13 hypertensive patients without LVH (m/f: 5/8,the mean age:62.4±4.9yrs). The blood samples was taken at fasting state and serums were kept at -80 0C until examined. Plasma leptin levels were determined by ELISA. The clinical and echocardiographic parameters and the mean plasma leptin levels were compared to each other. Results: We did not find any statistical significance between groups in terms of the treatment, the duration of hypertension and body mass index. The mean plasma leptin levels was 33.3±15.3 ng/ml in the group 1 whereas this was 28.3±17.6 ngr/ml in the group 2. There was not any statistical difference between them (p>0.05). Conclusion: The plasma leptin levels in hypertensive patients with LVH was not different from that in hypertensive patients without LVH. It may be concluded that there is not any effect of leptin on the development of LVH in hypertension.
Aims: Leptin, which is a hormone secreted by adipose tissue, has many effects on the sympathetic nervous system and other systems. It is well-known that hypertension is associated with high leptin levels. The aim of this study was to determine whether there is any effect of leptin on the development of left ventricular hypertrophy(LVH) in hypertensive patients. Material and methods: Forty hypertensive patients were enrolled to the study. The study population was divided into two groups according to LVH determined by echocardiography. Group 1 was consisted of 27 hypertensive patients with LVH(m/f: 9/18, the mean age:59.1±7.2yrs) while group 2 was composed of 13 hypertensive patients without LVH (m/f: 5/8,the mean age:62.4±4.9yrs). The blood samples was taken at fasting state and serums were kept at -80 0C until examined. Plasma leptin levels were determined by ELISA. The clinical and echocardiographic parameters and the mean plasma leptin levels were compared to each other. Results: We did not find any statistical significance between groups in terms of the treatment, the duration of hypertension and body mass index. The mean plasma leptin levels was 33.3±15.3 ng/ml in the group 1 whereas this was 28.3±17.6 ngr/ml in the group 2. There was not any statistical difference between them (p>0.05). Conclusion: The plasma leptin levels in hypertensive patients with LVH was not different from that in hypertensive patients without LVH. It may be concluded that there is not any effect of leptin on the development of LVH in hypertension.
Açıklama
Anahtar Kelimeler
Leptin, hipertansiyon, sol ventrikül hipertrofisi, Leptin, hypertension, left ventricular hypertrophy
Kaynak
Nobel Medicus
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
2
Sayı
1
Künye
Kardeşoğlu, E., Demiralp, E., Cebeci, B. S., Özmen, N., Çelik, T., Top, C., Cingözbay, B. Y. ve Yalçın, M. (2006). Hipertansif hastalarda sol ventrikül hipertrofisi gelişmesine leptin düzeylerinin etkisi / Effect of leptin on the development of left ventricular hypertrophy in hypertensive patients. Nobel Medicus, Nobel İlaç San. ve Tic. A.Ş. 2(1), s. 10-14.
