Neuroprotective effect of ziprasidone: Preliminary results compared to haloperidol

Basit Öğe Kaydı
dc.authorid0000-0003-3868-3137en_US
dc.authorid0000-0002-4713-4271en_US
dc.authorid0000-0002-8313-4092en_US
dc.authorid0000-0003-2016-9965en_US
dc.contributor.authorÇinar N.
dc.contributor.authorKarao?lan A.
dc.contributor.authorMidi A.
dc.contributor.authorÇal M.A.
dc.contributor.authorKelten B.
dc.contributor.authorÇakmak M.A.
dc.contributor.authorŞahin S.
dc.date.accessioned2024-07-12T21:50:43Z
dc.date.available2024-07-12T21:50:43Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractTypical and atypical antipsychotic drugs are widely used to treat psychosis. The present study investigated whether ziprasidone, an atypical antipsychotic drug, has a neuroprotective effect on hippocampal neurons in rats with experimentallyinduced transient cerebral ischemia comparatively with haloperidol which is a typical antipsychotic. Transient cerebral ischemia was induced by 10-minute occlusion of bilateral carotis communis arteries. The rats were divided into four groups: Shamoperated control group (Group I), ischemia control group (Group II), haloperidol-treated group (Group III) and ziprasidone-treated group (Group IV). Following 10-minute ischemia, Group III received 1mg/kg haloperidol intramuscularly and Group IV received 2.5 mg/kg ziprasidone intraperitoneally. The animals were sacrificed on the seventh day following induced ischemia to determine the number of intact neurons at hippocampus and dentate gyrus to demonstrate the effects of ischemia and efficacy of the treatments administered. Surviving cell numbers were found in the sham operated group; 198, in the ischemia control group; 80, in the haloperidol-treated group; 185, in ziprasidonetreated group; 189. The groups showed significant difference in the comparison of the surviving cell numbers. However, the number of surviving cells did not significantly different between the ziprasidone and haloperidol-treated group. Previous studies with the ischemia model have demonstrated protective effects of haloperidol on hippocampal region. The findings of the present study show that ziprasidone, which is an atypical antipsychotic drug, may produce neuroprotective effects as potent as haloperidol, which is a typical antipsychotic drug. © 2014 OMU.en_US
dc.identifier.doi10.5835/jecm.omu.31.02.002
dc.identifier.endpage75en_US
dc.identifier.issn1309-4483
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85006555700en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage71en_US
dc.identifier.urihttps://dx.doi.org/10.5835/jecm.omu.31.02.002
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8191
dc.identifier.volume31en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherOndokuz Mayis Universitesien_US
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01898
dc.subjectBrain ischemiaen_US
dc.subjectHaloperidolen_US
dc.subjectHippocampusen_US
dc.subjectNeuroprotective agentsen_US
dc.subjectZiprasidoneen_US
dc.titleNeuroprotective effect of ziprasidone: Preliminary results compared to haloperidolen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu