The Effects of Glutathione on Clinically Essential Fertility Parameters in a Bleomycin Etoposide Cisplatin Chemotherapy Model

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dc.authoridSelam, Belgin F/0000-0003-4478-7514en_US
dc.authoridBayram, Hale/0000-0002-6104-8820en_US
dc.authoridDönmez Çakıl, Yaprak/0000-0002-4605-1167en_US
dc.contributor.authorBayram, Hale
dc.contributor.authorDönmez Çakıl, Yaprak
dc.contributor.authorSitar, Mustafa Erinc
dc.contributor.authorDemirel, Gamze
dc.contributor.authorSelam, Belgin
dc.contributor.authorCincik, Mehmet
dc.date.accessioned2024-07-12T21:37:48Z
dc.date.available2024-07-12T21:37:48Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractChemotherapeutic agents used in the treatment of testicular cancer cause damage to healthy tissues, including the testis. We investigated the effects of glutathione on sperm DNA integrity and testicular histomorphology in bleomycin etoposide cisplatin (BEP) treated rats. Twelve-week-old male rats of reproductive age (n = 24) were randomly divided into three groups, the (i) control group, (ii) BEP group, and (iii) BEP+ glutathione group. Weight gain increase and testes indices of the control group were found to be higher than that of the BEP group and BEP+ glutathione group. While the BEP treatment increased sperm DNA fragmentation and morphological abnormalities when compared to the control group, GSH treatment resulted in a marked decrease for both parameters. Moreover, BEP treatment significantly decreased serum testosterone levels and sperm counts in comparison to the control group, yet this reduction was recovered in the BEP+ glutathione treated group. Similarly, seminiferous tubule epithelial thicknesses and Johnsen scores in testicles were higher in the control and BEP+ glutathione groups than in the BEP-treated group. In conclusion, exogenous glutathione might prevent the deterioration of male reproductive functions by alleviating the detrimental effects of BEP treatment on sperm quality and testicular histomorphology.en_US
dc.identifier.doi10.3390/life13030815
dc.identifier.issn2075-1729
dc.identifier.issue3en_US
dc.identifier.pmid36983969en_US
dc.identifier.scopus2-s2.0-85151356464en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.3390/life13030815
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6946
dc.identifier.volume13en_US
dc.identifier.wosWOS:000959051200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofLife-Baselen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04288
dc.subjectBleomycinen_US
dc.subjectChemotherapyen_US
dc.subjectCisplatinen_US
dc.subjectDna Fragmentationen_US
dc.subjectEtoposideen_US
dc.subjectGlutathioneen_US
dc.subjectSpermatozoaen_US
dc.titleThe Effects of Glutathione on Clinically Essential Fertility Parameters in a Bleomycin Etoposide Cisplatin Chemotherapy Modelen_US
dc.typeArticle
dspace.entity.typePublication

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