Effects of Chronic and Intermittent Calorie Restriction on Adropin Levels in Breast Cancer

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dc.authorid0000-0003-1348-1336en_US
dc.authorid0000-0002-7762-8109en_US
dc.contributor.authorTuna, Bilge G.
dc.contributor.authorAtalay, Pinar B.
dc.contributor.authorAltunbek, Mine
dc.contributor.authorKalkan, Batuhan M.
dc.contributor.authorDogan, Soner
dc.date.accessioned2024-07-12T21:52:36Z
dc.date.available2024-07-12T21:52:36Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAdropin is a peptide hormone that has been implicated in insulin resistance and as a potential regulator of growth. The aim of this study is to determine the effect of calorie restriction on circulating levels of adropin in the MMTV-TGF breast cancer mouse model and investigate the effects of adropin peptide on the viability of MCF-7 and MDA-231 breast cancer cells in culture. Ten-week-old mice were assigned to either ad libitum-fed (AL), chronic calorie-restricted, or intermittent calorie-restricted groups. Concentrations of serum adropin were measured using an enzyme-linked immunosorbent assay. Results showed an inverse correlation between serum adropin levels and mouse age that was attenuated by calorie restriction. In the AL group the level of adropin was significantly lower at week 50 compared to levels at week 10. However, among the calorie-restricted groups, serum levels of adropin remained high at week 50. The cell-line-specific effects were observed after treatment of cancer cell lines with a series of adropin concentrations (5, 10, 25, 50ng/mL). Flow cytometry analysis showed that MCF-7 cells entered the early phase of apoptosis after treatment with 50ng/mL for 24h. Adropin may be involved in the protective effects that calorie restriction has on breast cancer risk.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [114S429]en_US
dc.description.sponsorshipWe thank Dr. Margot P. Cleary for generously donating the breeding colony of the MMTV-TGF alpha transgenic mice and Dr. Kathleen Arcaro and Christopher Bergweiler for kindly editing the manuscript. This research was funded by the Scientific and Technological Research Council of Turkey (TUBITAK, 114S429). We also thank Yeditepe University Animal Facility Employees and student assistants Ilker Coban, Burcu Cicekdal, and Goktug Karabiyik for their help for handling and taking care of animals.en_US
dc.identifier.doi10.1080/01635581.2017.1359314
dc.identifier.endpage1010en_US
dc.identifier.issn0163-5581
dc.identifier.issn1532-7914
dc.identifier.issue7en_US
dc.identifier.pmid28922017en_US
dc.identifier.scopus2-s2.0-85029585757en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1003en_US
dc.identifier.urihttps://dx.doi.org/10.1080/01635581.2017.1359314
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8408
dc.identifier.volume69en_US
dc.identifier.wosWOS:000415755000005en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTDen_US
dc.relation.ispartofNUTRITION AND CANCER-AN INTERNATIONAL JOURNALen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03152
dc.titleEffects of Chronic and Intermittent Calorie Restriction on Adropin Levels in Breast Canceren_US
dc.typeArticle
dspace.entity.typePublication

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