Anticancer Use of Nanoparticles as Nucleic Acid Carriers

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dc.authorid0000-0001-6283-6717en_US
dc.authorid0000-0001-7739-2346en_US
dc.authorid0000-0003-4062-9519en_US
dc.contributor.authorGozuacik, D.
dc.contributor.authorYagci-Acar, H. F.
dc.contributor.authorAkkoc, Y.
dc.contributor.authorKosar, A.
dc.contributor.authorDogan-Ekici, A. Isin
dc.contributor.authorEkici, Sinan
dc.date.accessioned2024-07-12T21:58:07Z
dc.date.available2024-07-12T21:58:07Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractAdvances in nanotechnology opened up new horizons in the field of cancer research. Nanoparticles made of various organic and inorganic materials and with different optical, magnetic and physical characteristics have the potential to revolutionize the way we diagnose, treat and follow-up cancers. Importantly, designs that might allow tumor-specific targeting and lesser side effects may be produced. Nanoparticles may be tailored to carry conventional chemotherapeutics or new generation organic drugs. Currently, most of the drugs that are commonly used, are small chemical molecules targeting disease-related enzymes. Recent progress in RNA interference technologies showed that, even proteins that are considered to be "undruggable" by small chemical molecules, might be targeted by small RNAs for the purpose of curing diseases, including cancer. In fact, small RNAs such as siRNAs, shRNAs and miRNAs can drastically change cellular levels of almost any given disease-associated protein or protein group, resulting in a therapeutic effect. Gene therapy attempts were failing mainly due to delivery viral vector-related side effects. Biocompatible, non-toxic and efficient nanoparticle carriers raise new hopes for the gene therapy of cancer. In this review article, we discuss new advances in nucleic acid and especially RNA carrier nanoparticles, and summarize recent progress about their use in cancer therapy.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey-1001 (TUBITAK-1001) [112T272]; European Molecular Biology Organization (EMBO); Sabanci and Koc Universities; EMBO-SDIG Award; TUBITAK Incentive Award; Turkish Academy of Sciences (TUBA) GEBIP Award; L'OREAL Turkey National Fellowship for Women in Science; TUBITAK-BIDEB Scholarship for Ph.D.studiesen_US
dc.description.sponsorshipThis work was supported by Scientific and Technological Research Council of Turkey-1001 (TUBITAK-1001 Grant number: 112T272), European Molecular Biology Organization (EMBO), Sabanci and Koc Universities. D. Gozuacik is a recipient of EMBO-SDIG Award. A. Kosar received TUBITAK Incentive Award. D. Gozuacik and A. Kosar are recipients of Turkish Academy of Sciences (TUBA) GEBIP Award. H. F. Yagci-Acar is a recipient of L'OREAL Turkey National Fellowship for Women in Science. Y. Akkoc is supported by TUBITAK-BIDEB Scholarship for Ph.D. studies.en_US
dc.identifier.doi10.1166/jbn.2014.1935
dc.identifier.endpage1783en_US
dc.identifier.issn1550-7033
dc.identifier.issn1550-7041
dc.identifier.issue9en_US
dc.identifier.pmid25992440en_US
dc.identifier.scopus2-s2.0-84904886096en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1751en_US
dc.identifier.urihttps://dx.doi.org/10.1166/jbn.2014.1935
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8759
dc.identifier.volume10en_US
dc.identifier.wosWOS:000339430600006en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAMER SCIENTIFIC PUBLISHERSen_US
dc.relation.ispartofJOURNAL OF BIOMEDICAL NANOTECHNOLOGYen_US
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY09274
dc.subjectCanceren_US
dc.subjectDrugen_US
dc.subjectChemotherapyen_US
dc.subjectNanomedicineen_US
dc.subjectNanoparticlesen_US
dc.subjectRNA Interferenceen_US
dc.subjectsiRNAen_US
dc.subjectshRNAen_US
dc.subjectmicroRNAen_US
dc.subjectNanocarriersen_US
dc.subjectTargeted Therapyen_US
dc.titleAnticancer Use of Nanoparticles as Nucleic Acid Carriersen_US
dc.typeReview
dspace.entity.typePublication

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