Mycobacterium tuberculosis strains isolated from Van region four different sensitivity detection method antimycobacterial agents [Van yöresinde izole edilen Mycobacterium tuberculosis suşlari{dotless}ni{dotless}n dört farkli{dotless} yöntemle antimikobakteriyel ajanlara duyarli{dotless}li{dotless}k tespiti]

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dc.authorid0000-0001-5278-0174en_US
dc.contributor.authorBaykal E.S.
dc.contributor.authorGüdücüoglu H.
dc.contributor.authorYaman G.
dc.contributor.authorBerktaş M.
dc.date.accessioned2024-07-12T21:53:36Z
dc.date.available2024-07-12T21:53:36Z
dc.date.issued2014en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIntroduction: The purpose of this study is detecting the susceptibility rates of 58 Mycobacterium tuberculosis complex strains which were isolated from patient specimens sent to our mycobacteriology laboratory, for major anti-tuberculosis drugs like streptomycin, isoniazid, rifampicin and ethambutol with three different systems and agar proportion method and compare the accessibility, speed, specificity and sensitivity of these three systems. Materials and Methods: With this purpose, 58 (96.6%) strains out of 60 which were isolated from the patients attended to the mycobacteriology laboratory were identified as M. tuberculosis complex with conventional methods. These strains susceptibilities to four major anti-tuberculosis drugs were detected with Manuel MGIT AST SIRE system, BacT/ALERT 3D system MB/BacT SIRE, TK anti-TB system and compared with reference method in Middlebrook 7H10 media. Results: As a result, INH resistance in Van province with agar proportion method was detected as 12%, followed by INH + RIF resistance of 1.7% and INH + SM resistance of 1.7%. These result compared with other studies conducted country wide are in median range. The systems included in our study were determined to have 100% sensitivity for all of the drugs for detecting resistance and sensitivity rates. Specificities for INH for TK anti-TB, MGIT and MB/BacT were detected as 98%, 96% and 95% respectively. Multidrug resistance rates were detected in 100% sensitivity and specificity with all of the three systems. Only MB/BacT system gave a false negative RIF resistance for 1 strain. Fastest system according to resistance determination times is found to be the MGIT system. Conclusion: However, presence of INH + RIF resistance pattern, indicates inadequate treatment programs in our region. As a result these three systems are fast and reliable systems for antimicrobial susceptibility testing of Mycobacterium spp. to be used in routine mycobacteriology laboratories.en_US
dc.identifier.doi10.5578/tt.7323
dc.identifier.endpage130en_US
dc.identifier.issn0494-1373
dc.identifier.issue2en_US
dc.identifier.pmid25038381en_US
dc.identifier.scopus2-s2.0-84904461355en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage122en_US
dc.identifier.urihttps://dx.doi.org/10.5578/tt.7323
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8522
dc.identifier.volume62en_US
dc.identifier.wosWOS:000421339200004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherAnkara Universityen_US
dc.relation.ispartofTuberkuloz ve Toraksen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03632
dc.titleMycobacterium tuberculosis strains isolated from Van region four different sensitivity detection method antimycobacterial agents [Van yöresinde izole edilen Mycobacterium tuberculosis suşlari{dotless}ni{dotless}n dört farkli{dotless} yöntemle antimikobakteriyel ajanlara duyarli{dotless}li{dotless}k tespiti]en_US
dc.typeArticle
dspace.entity.typePublication

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