Integrating mitoepigenetics into research in mood disorders: a state-of-the-art review

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dc.contributor.authorCeylan, Deniz
dc.contributor.authorArat-Çelik, Hidayet Ece
dc.contributor.authorAkŞahin, Izel Cemre
dc.date.accessioned2024-07-12T21:40:55Z
dc.date.available2024-07-12T21:40:55Z
dc.date.issued2024en_US
dc.department[Belirlenecek]en_US
dc.description.abstractMood disorders, including major depressive disorder and bipolar disorder, are highly prevalent and stand among the leading causes of disability. Despite the largely elusive nature of the molecular mechanisms underpinning these disorders, two pivotal contributors-mitochondrial dysfunctions and epigenetic alterations-have emerged as significant players in their pathogenesis. This state-of-the-art review aims to present existing data on epigenetic alterations in the mitochondrial genome in mood disorders, laying the groundwork for future research into their pathogenesis. Associations between abnormalities in mitochondrial function and mood disorders have been observed, with evidence pointing to notable changes in mitochondrial DNA (mtDNA). These changes encompass variations in copy number and oxidative damage. However, information on additional epigenetic alterations in the mitochondrial genome remains limited. Recent studies have delved into alterations in mtDNA and regulations in the mitochondrial genome, giving rise to the burgeoning field of mitochondrial epigenetics. Mitochondrial epigenetics encompasses three main categories of modifications: mtDNA methylation/hydroxymethylation, modifications of mitochondrial nucleoids, and mitochondrial RNA alterations. The epigenetic modulation of mitochondrial nucleoids, lacking histones, may impact mtDNA function. Additionally, mitochondrial RNAs, including non-coding RNAs, present a complex landscape influencing interactions between the mitochondria and the nucleus. The exploration of mitochondrial epigenetics offers valuable perspectives on how these alterations impact neurodegenerative diseases, presenting an intriguing avenue for research on mood disorders. Investigations into post-translational modifications and the role of mitochondrial non-coding RNAs hold promise to unravel the dynamics of mitoepigenetics in mood disorders, providing crucial insights for future therapeutic interventions.en_US
dc.description.sponsorshipTUBITAK [122Z771]; Koc Universityen_US
dc.description.sponsorshipThe author(s) declare financial support was received for the research, authorship, and/or publication of this article. This review article has been conducted within the scope of the TUBITAK 1001 project with the number 122Z771.Additionally, support from Koc University has been obtained for its publication.en_US
dc.identifier.doi10.3389/fphys.2024.1338544
dc.identifier.issn1664-042X
dc.identifier.pmid38410811en_US
dc.identifier.scopus2-s2.0-85185945610en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.3389/fphys.2024.1338544
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7555
dc.identifier.volume15en_US
dc.identifier.wosWOS:001169958200001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherFrontiers Media Saen_US
dc.relation.ispartofFrontiers in Physiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY09433
dc.subjectMood Disordersen_US
dc.subjectBipolar Disorderen_US
dc.subjectMajor Depressionen_US
dc.subjectEpigeneticsen_US
dc.subjectMitochondrial Dysfunctionen_US
dc.subjectMitoepigeneticsen_US
dc.titleIntegrating mitoepigenetics into research in mood disorders: a state-of-the-art reviewen_US
dc.typeReview Article
dspace.entity.typePublication

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