Nitric oxide, endothelin-1, and superoxide production in arterial bypass grafts

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dc.contributor.authorAksungar F.B.
dc.contributor.authorMoini H.
dc.contributor.authorUnal M.
dc.contributor.authorYilmaz O.
dc.contributor.authorSonmez B.
dc.contributor.authorBilsel S.
dc.date.accessioned2024-07-12T21:53:27Z
dc.date.available2024-07-12T21:53:27Z
dc.date.issued2006en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractIn this study, basal and thrombin-stimulated release of nitric oxide and endothelin-1 in the internal mammary artery and the radial artery were measured, together with superoxide radicals generated after anoxia and reoxygenation. Arterial segments were obtained from patients undergoing coronary bypass operations. Quantification of nitric oxide was performed by measuring the stable oxidation products of nitric oxide. Endothelin levels were measured by an enzyme immunoassay kit, and the superoxides were measured by lucigenin-enhanced chemiluminescence. Basal and stimulated release of nitric oxide from the internal mammary artery is significantly higher than that in the radial artery. On the other hand, basal release of endothelin-1 is less in the internal mammary artery than in the radial artery, but similar after stimulation. In our study, the quantity of superoxide radicals produced by the internal mammary artery was greater than that produced by the radial artery. Our results show that there are differences between these 2 arteries in regard to production of nitric oxide, endothelin-1, and superoxide radicals. These differences may have a role in the process of atherogenesis and may contribute to long-term patency of arterial bypass grafts. These results may also explain the mechanism of radial artery graft spasm in coronary artery surgery and may constitute a basis for future pharmacological and clinical improvements for successful surgical application. © 2006 by the Texas Heart® Institute.en_US
dc.identifier.endpage299en_US
dc.identifier.issn0730-2347
dc.identifier.issue3en_US
dc.identifier.pmid17041684en_US
dc.identifier.scopus2-s2.0-33750584139en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage294en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8503
dc.identifier.volume33en_US
dc.identifier.wosWOS:000240700500004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofTexas Heart Institute Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY03493
dc.subjectEndothelinen_US
dc.subjectInternal mammary arteryen_US
dc.subjectNitric oxideen_US
dc.subjectRadial arteryen_US
dc.subjectSuperoxideen_US
dc.titleNitric oxide, endothelin-1, and superoxide production in arterial bypass graftsen_US
dc.typeArticle
dspace.entity.typePublication

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