A new non-linear optimization of parameters in Michaelis-Menten kinetics
Küçük Resim Yok
Tarih
2009
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Maltepe Üniversitesi
Erişim Hakkı
CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
A new non-linear optimization of parameters in Michaelis-Menten equation has been developed. This method is based on special mathematical form of Michaelis-Menten equation and finding best fitting line of R versus S/ (S +Km). By trying to tend the intercept to zero, the proper Km will be obtained. At the founded Km, the slope is equal to Vm. In this method a non-linear, two-parameter optimization is changed into finding a root of non-linear equation. Generated data set is used to introduce this new method. Data set from literature is used to illustrate accuracy of this technique in comparison with linearization methods. Results show that accuracy of the mentioned method is better than Lineweaver-Burk, Eddie and Hanes methods.
Açıklama
Anahtar Kelimeler
Kaynak
International Conference of Mathematical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Heydari, A. (2009). A new non-linear optimization of parameters in Michaelis-Menten kinetics. Maltepe Üniversitesi. s. 99.
