A new non-linear optimization of parameters in Michaelis-Menten kinetics
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2009
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Maltepe Üniversitesi
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CC0 1.0 Universal
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Abstract
A new non-linear optimization of parameters in Michaelis-Menten equation has been developed. This method is based on special mathematical form of Michaelis-Menten equation and finding best fitting line of R versus S/ (S +Km). By trying to tend the intercept to zero, the proper Km will be obtained. At the founded Km, the slope is equal to Vm. In this method a non-linear, two-parameter optimization is changed into finding a root of non-linear equation. Generated data set is used to introduce this new method. Data set from literature is used to illustrate accuracy of this technique in comparison with linearization methods. Results show that accuracy of the mentioned method is better than Lineweaver-Burk, Eddie and Hanes methods.
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International Conference of Mathematical Sciences
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Heydari, A. (2009). A new non-linear optimization of parameters in Michaelis-Menten kinetics. Maltepe Üniversitesi. s. 99.
