Lost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severity

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dc.authoridQuigley, Eamonn/0000-0003-4151-7180en_US
dc.authoridBarrows, Brad/0000-0003-4069-525Xen_US
dc.contributor.authorHazan, Sabine
dc.contributor.authorStollman, Neil
dc.contributor.authorBozkurt, Hüseyin S.
dc.contributor.authorDave, Sonya
dc.contributor.authorPapoutsis, Andreas J.
dc.contributor.authorDaniels, Jordan
dc.contributor.authorBarrows, Brad D.
dc.date.accessioned2024-07-12T21:37:46Z
dc.date.available2024-07-12T21:37:46Z
dc.date.issued2022en_US
dc.department[Belirlenecek]en_US
dc.description.abstractObjective The study objective was to compare gut microbiorne diversity and composition in SARS-CoV-2 PCR-positive patients whose symptoms ranged from asymptomatic to severe versus PCR-negative exposed controls. Design Using a cross-sectional design, we performed shotgun next-generation sequencing on stool samples to evaluate gut microbiome composition and diversity in both patients with SARS-CoV-2 PCR-confirmed infections, which had presented to Ventura Clinical Trials for care from March 2020 through October 2021 and SARS-CoV-2 PCR-negative exposed controls. Patients were classified as being asymptomatic or having mild, moderate or severe symptoms based on National Institute of Health criteria. Exposed controls were individuals with prolonged or repeated close contact with patients with SARS-CoV-2 infection or their samples, for example, household members of patients or frontline healthcare workers. Microbiome diversity and composition were compared between patients and exposed controls at all taxonomic levels. Results Compared with controls (n=20), severely symptomatic SARS-CoV-2-infected patients (n=28) had significantly less bacterial diversity (Shannon Index, p=0.0499; Simpson Index, p=0.0581), and positive patients overall had lower relative abundances of Bffidobacteriutn (p<0.0001), Faecalibacteriutn (p=0.0077) and Rosebutiunt (p=0.0327), while having increased Bacteroides (p=0.0075). Interestingly, there was an inverse association between disease severity and abundance of the same bacteria. Conclusion We hypothesise that low bacterial diversity and depletion of Bifidobacterium genera either before or after infection led to reduced proimmune function, thereby allowing SARS-CoV-2 infection to become symptomatic. This particular dysbiosis pattern may be a susceptibility marker for symptomatic severity from SARS-CoV-2 infection and may be amenable to preinfection, intrainfection or postinfection intervention.en_US
dc.identifier.doi10.1136/bmjgast-2022-000871
dc.identifier.issn2054-4774
dc.identifier.issue1en_US
dc.identifier.pmid35483736en_US
dc.identifier.scopus2-s2.0-85130967943en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1136/bmjgast-2022-000871
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6933
dc.identifier.volume9en_US
dc.identifier.wosWOS:000789490800001en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBmj Publishing Groupen_US
dc.relation.ispartofBmj Open Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04275
dc.titleLost microbes of COVID-19: Bifidobacterium, Faecalibacterium depletion and decreased microbiome diversity associated with SARS-CoV-2 infection severityen_US
dc.typeArticle
dspace.entity.typePublication

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