Effects of venlafaxine on ethanol withdrawal syndrome in rats

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dc.authorid0000-0002-6423-4207en_US
dc.authorid0000-0002-0021-8400en_US
dc.contributor.authorSaglam, E
dc.contributor.authorUzbay, IT
dc.contributor.authorKayir, H
dc.contributor.authorCelik, T
dc.contributor.authorBeyazyurek, M
dc.date.accessioned2024-07-12T21:47:06Z
dc.date.available2024-07-12T21:47:06Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractThe present study was designed to investigate the effects of venlafaxine, a serotonin and noradrenaline reuptake inhibitor (SNRI), on ethanol withdrawal syndrome in rats. Adult male Wistar rats (187-319 g) were used for the study. Ethanol (7.2%, v/v) was given to rats by a liquid diet for 21 days. Control rats were pair-fed an isocaloric liquid diet containing sucrose as a caloric substitute to ethanol. Venlafaxine (5, 10, 20 and 40 mg/kg) and saline were injected to rats intraperitoneally just before ethanol withdrawal. After the 2nd, 4th and 6th hour of ethanol withdrawal, rats were observed for 5 min, and withdrawal signs that included locomotor hyperactivity, agitation, stereotyped behaviour and wet dog shakes were recorded or rated. A second series of injections was given at the 6th hour after the first one, and rats were then tested for audiogenic seizures. Venlafaxine produced some inhibitory effects on locomotor hyperactivity, stereotypic behaviours and wet dog shakes. However, a two-way ANOVA of the data did not indicate any significant effect. It reduced the incidence of the audiogenic seizures at the 6th hour of ethanol withdrawal. Venlafaxine (20 mg/kg) also prolonged the latency of the seizures significantly. Our results suggest that acute venlafaxine treatment has limited beneficial effects on ethanol withdrawal syndrome in rats.en_US
dc.identifier.doi10.1111/j.1472-8206.2004.00281.x
dc.identifier.endpage698en_US
dc.identifier.issn0767-3981
dc.identifier.issn1472-8206
dc.identifier.issue6en_US
dc.identifier.pmid15548241en_US
dc.identifier.scopus2-s2.0-9444283781en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage693en_US
dc.identifier.urihttps://dx.doi.org/10.1111/j.1472-8206.2004.00281.x
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8006
dc.identifier.volume18en_US
dc.identifier.wosWOS:000225737800012en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWILEYen_US
dc.relation.ispartofFUNDAMENTAL & CLINICAL PHARMACOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01061
dc.subjectethanol dependenceen_US
dc.subjectethanol withdrawal syndromeen_US
dc.subjectrat(s)en_US
dc.subjectvenlafaxineen_US
dc.titleEffects of venlafaxine on ethanol withdrawal syndrome in ratsen_US
dc.typeArticle
dspace.entity.typePublication

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