Effects of ACE polymorphisms and other risk factors on the severity of coronary artery disease

Basit Öğe Kaydı
dc.contributor.authorGuney, A. I.
dc.contributor.authorErgec, D.
dc.contributor.authorKirac, D.
dc.contributor.authorOzturhan, H.
dc.contributor.authorCaner, M.
dc.contributor.authorKoc, G.
dc.contributor.authorKaspar, C.
dc.contributor.authorUlucan, K.
dc.contributor.authorAgirbasli, M.
dc.date.accessioned2024-07-12T21:47:08Z
dc.date.available2024-07-12T21:47:08Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractCoronary artery disease (CAD) is a multifactorial disease influenced by genetic and environmental factors. Major risk factors of CAD are hypertension, hyperlipidemia, smoking, family history and obesity. Also polymorphisms in the angiotensin-I converting enzyme (ACE) gene can associate with CAD. The relationship between ACE polymorphisms and other risk factors is not well understood in CAD, likely due to the complex interrelation of genetic and environmental risk factors. The aim of this study was to investigate the associations of CAD risk factors and ACE polymorphisms in patients with CAD. We enrolled 203 consecutive patients and 140 healthy subjects in the study. The severity of CAD was evaluated according to the number of vessels with significant stenosis. ACE insertion (I)/deletion (D) genotype was determined by PCR. The frequency of the DD genotype was significantly higher in patients. D allele frequency was higher among CAD subjects when compared to the control group. The number of stenotic vessels were found to be statistically associated with a high frequency of DD polymorphism and D allele and a low frequency of I allele in patients, especially in male patients. The control group displayed II and ID genotypes more frequently than did the patients. The ACE I/D genotype was associated with hyperlipidemia and smoking history. We consider that the DD polymorphism and D allele may affect the severity of CAD, while I allele may have a protective effect. In conclusion, the ACE I/D genotype may interact with conventional risk criteria in determining the risk of CAD.en_US
dc.identifier.doi10.4238/2013.December.19.8
dc.identifier.endpage6906en_US
dc.identifier.issn1676-5680
dc.identifier.issue4en_US
dc.identifier.pmid24391037en_US
dc.identifier.scopus2-s2.0-84891106761en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage6895en_US
dc.identifier.urihttps://dx.doi.org/10.4238/2013.December.19.8
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8012
dc.identifier.volume12en_US
dc.identifier.wosWOS:000331608000279en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherFUNPEC-EDITORAen_US
dc.relation.ispartofGENETICS AND MOLECULAR RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01079
dc.subjectMultifactorial diseaseen_US
dc.subjectHyperlipidemiaen_US
dc.subjectObesityen_US
dc.subjectSmokingen_US
dc.subjectAngiotensin-I coverting enzymeen_US
dc.titleEffects of ACE polymorphisms and other risk factors on the severity of coronary artery diseaseen_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu