Evaluation of substance induced and substance free first-episode psychosis in terms of inflammatory whole blood count parameters

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dc.contributor.authorÇelik, Hidayet Ece Arat
dc.date.accessioned2024-07-12T21:40:20Z
dc.date.available2024-07-12T21:40:20Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractObjective: Substance use is known to trigger psychotic episodes in individuals predisposed to psychosis. Recently, the importance of inflammatory processes in psychotic disorders has been increasingly emphasized. This study aimed to examine the manner in which inflammatory whole blood count (WBC) parameters change in substance-induced first-episode psychosis (siFEP) and substance-free first-episode psychosis (sfFEP). Method: The present study included 32 patients with siFEP, 48 patients with sfFEP, and 80 healthy controls. For the comparison of inflammatory WBC parameters between the three groups, age and sex were considered as covariates when MANCOVA was applied; further, LSD post hoc test was performed. The relationship between clinical variables and inflammatory WBC parameters was analyzed using Pearson's correlation analysis. Results: Monocyte levels were higher in patients with siFEP than in those with sfFEP and healthy controls, and platelet-to-lymphocyte ratio values were lower in patients with siFEP than in healthy controls. Furthermore, a moderately significant relationship between duration of illness and monocyte levels was found in the siFEP group. Discussion: The fact that inflammatory WBC parameters differ among the siFEP, sfFEP, and healthy control groups suggests that inflammatory processes contribute to psychotic disorder. However, the data from the present study are still insufficient to support the use of these parameters in clinical practice.en_US
dc.identifier.doi10.5505/kpd.2023.14564
dc.identifier.endpage176en_US
dc.identifier.issn1302-0099
dc.identifier.issn2146-7153
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-85173187671en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage170en_US
dc.identifier.urihttps://doi.org/10.5505/kpd.2023.14564
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7248
dc.identifier.volume26en_US
dc.identifier.wosWOS:001094376800004en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherKlinik Psikiyatri Dergisien_US
dc.relation.ispartofKlinik Psikiyatri Dergisi-Turkish Journal of Clinical Psychiatryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY05204
dc.subjectFirst-Episode Psychosisen_US
dc.subjectSubstance-Induced First-Episode Psychosisen_US
dc.subjectSubstance-Free First-Episode Psychosisen_US
dc.subjectInflammatory Whole Blood Count Parametersen_US
dc.titleEvaluation of substance induced and substance free first-episode psychosis in terms of inflammatory whole blood count parametersen_US
dc.typeArticle
dspace.entity.typePublication

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