Outcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective study

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dc.authoridSUNER, ASLI/0000-0002-6872-9901en_US
dc.authoridBuğdaycı, Onur/0000-0002-6011-2720en_US
dc.authoridEsen Icten, Gül/0000-0001-6821-8696en_US
dc.authoridRona, Günay/0000-0002-0304-029Xen_US
dc.authoridBaşara Akın, Işıl/0000-0002-0786-1490en_US
dc.authoridAribal, Erkin/0000-0002-5525-8696en_US
dc.authoridİkizceli, Türkan/0000-0002-5683-0391en_US
dc.contributor.authorOktay, Ayşenur
dc.contributor.authorAslan, Özge
dc.contributor.authorTaşkın, Füsun
dc.contributor.authorTunçbilek, Nermin
dc.contributor.authorIcten, Selma Gül Esen
dc.contributor.authorBalci, Pınar
dc.contributor.authorAribal, Mustafa Erkin
dc.date.accessioned2024-07-12T21:37:50Z
dc.date.available2024-07-12T21:37:50Z
dc.date.issued2023en_US
dc.department[Belirlenecek]en_US
dc.description.abstractPURPOSE The clinical management of high-risk lesions using image-guided biopsy is challenging. This study aimed to evaluate the rates at which such lesions were upgraded to malignancy and identify possible predictive factors for upgrading high-risk lesions. METHODS This retrospective multicenter analysis included 1.343 patients diagnosed with high-risk lesions using an image-guided core needle or vacuum-assisted biopsy (VAB). Only patients managed using an excisional biopsy or with at least one year of documented radiological follow-up were included. For each, the Breast Imaging Reporting and Data System (BI-RADS) category, number of samples, needle thickness, and lesion size were correlated with malignancy upgrade rates in different histologic subtypes. Pearson's chi-squared test, the Fisher-Freeman-Halton test, and Fisher's exact test were used for the sta-tistical analyses. RESULTS The overall upgrade rate was 20.6%, with the highest rates in the subtypes of intraductal papilloma (IP) with atypia (44.7%; 55/123), followed by atypical ductal hyperplasia (ADH) (38.4%; 144/375), lobular neoplasia (LN) (12.7%; 7/55), papilloma without atypia (9.4%; 58/611), flat epithelial atypia (FEA) (8.7%; 10/114), and radial scars (RSs) (4.6%; 3/65). There was a significant relationship between the upgrade rate and BI-RADS category, number of samples, and lesion size Lesion size was the most predictive factor for an upgrade in all subtypes.CONCLUSION ADH and atypical IP showed considerable upgrade rates to malignancy, requiring surgical excision. The LN, IP without atypia, pure FEA, and RS subtypes showed lower malignancy rates when the BI-RADS category was lower and in smaller lesions that had been adequately sampled using VAB. After being discussed in a multidisciplinary meeting, these cases could be managed with follow-up instead of excision.en_US
dc.identifier.doi10.4274/dir.2022.221790
dc.identifier.endpage587en_US
dc.identifier.issn1305-3612
dc.identifier.issue4en_US
dc.identifier.pmid36994925en_US
dc.identifier.scopus2-s2.0-85165517456en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage579en_US
dc.identifier.urihttps://doi.org/10.4274/dir.2022.221790
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6956
dc.identifier.volume29en_US
dc.identifier.wosWOS:001050630500003en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherTurkish Soc Radiologyen_US
dc.relation.ispartofDiagnostic And Interventional Radiologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY04298
dc.subjectCore Needle Biopsyen_US
dc.subjectB3 Lesionsen_US
dc.subjectBreast Canceren_US
dc.subjectImage Guided Breast Biopsyen_US
dc.subjectVacuum Assisted Biopsyen_US
dc.titleOutcomes of high-risk breast lesions diagnosed using image-guided core needle biopsy: results from a multicenter retrospective studyen_US
dc.typeArticle
dspace.entity.typePublication

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