Plasma matrix metalloproteinase-9 level change with omalizumab treatment in chronic spontaneous urticaria
dc.contributor.author | Falay Gür, Tuğba | |
dc.contributor.author | Erdoğan, Sevil Savas | |
dc.contributor.author | Özcelik, Fatih | |
dc.contributor.author | Gurel, Mehmet Salih | |
dc.contributor.author | Dogan, Bilal | |
dc.date.accessioned | 2024-07-12T21:40:09Z | |
dc.date.available | 2024-07-12T21:40:09Z | |
dc.date.issued | 2021 | en_US |
dc.department | [Belirlenecek] | en_US |
dc.description.abstract | Background Matrix metalloproteinase-9 (MMP-9) is an enzyme that contributes to inflammation and tissue remodelling. In chronic urticaria, increased plasma levels of MMP-9 and its correlation with disease severity have been shown in several studies, suggesting that MMP-9 could be used to evaluate the effects of new treatments. We aimed to compare MMP-9 levels in chronic urticaria patients with those of healthy patients. Then we planned to investigate the changes in plasma MMP-9 levels with chronic urticaria treatment, the role of this enzyme in demonstrating the efficacy of treatment, and its correlation with C-reactive protein (CRP). Methods Forty-one patients with chronic urticaria who were scheduled for omalizumab treatment and 41 sex- and age-matched healthy volunteers were included in the study. In the patient group, before treatment and at the end of the 12th week, the urticaria activity score used for 7 consecutive days (UAS7) was calculated, and the MMP-9 and CRP levels were measured. Plasma MMP-9 levels were measured from venous blood in the control group. Results The plasma MMP-9 levels of the patients before treatment were significantly higher than those of the control group (P < .01). In the patient group, there was no significant relationship between the UAS7 score and the MMP-9 and CRP levels before treatment. The UAS7 values were 28 +/- 7 before omalizumab treatment and 5 +/- 6 at the end of the 12th week (P < .0001). The post-treatment MMP-9 levels (1818 +/- 297 pg/mL) were higher compared with the pre-treatment values (1617 +/- 380) (P < .05). The post-treatment CRP levels of the patients (2.41 +/- 2.17 mg/L) were lower than their pre-treatment CRP levels (8.20 +/- 19.70) (P < .05). Conclusion MMP-9 levels were not associated with the severity of disease, and MMP-9 levels were not decreased with treatment response. Therefore, MMP-9 cannot be used as a parameter of disease activity in chronic urticaria or to evaluate the efficacy of new treatments. | en_US |
dc.description.sponsorship | Turkish Society of Dermatology | en_US |
dc.description.sponsorship | This study was supported by the Turkish Society of Dermatology. | en_US |
dc.identifier.doi | 10.1111/ijcp.14942 | |
dc.identifier.issn | 1368-5031 | |
dc.identifier.issn | 1742-1241 | |
dc.identifier.issue | 12 | en_US |
dc.identifier.pmid | 34610203 | en_US |
dc.identifier.scopus | 2-s2.0-85116762320 | en_US |
dc.identifier.scopusquality | Q2 | en_US |
dc.identifier.uri | https://doi.org/10.1111/ijcp.14942 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12415/7161 | |
dc.identifier.volume | 75 | en_US |
dc.identifier.wos | WOS:000705143800001 | en_US |
dc.identifier.wosquality | Q2 | en_US |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | en_US |
dc.publisher | Wiley-Hindawi | en_US |
dc.relation.ispartof | International Journal of Clinical Practice | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.snmz | KY05028 | |
dc.title | Plasma matrix metalloproteinase-9 level change with omalizumab treatment in chronic spontaneous urticaria | en_US |
dc.type | Article | |
dspace.entity.type | Publication |