N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer
Küçük Resim Yok
Tarih
2010
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springerlink
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Polymorphisms that alter the function of genes involved in the activation or detoxification of carcinogenic compounds can influence an individuals risk of developing cancer. Polymorphic changes modulating the acetylation capacity of the N-acetyltransferase (NAT) genes have been implicated in the risk of developing cancer. In this study the role of genetically determined individual NAT1 and NAT2 genotypes, haplotypes and haplotype combinations in the predisposition to head and neck cancer was investigated. Polymorphic regions of the NAT1 and NAT2 genes were analyzed in patients with head and neck cancer and healthy individuals by polymerase chain reaction-restriction fragment length polymorphism. Distribution of the genotypes, allele frequencies, diplotypes and haplotypes and correlation with clinical characteristics were evaluated. No association was observed between the NAT1*3, NAT1*10, NAT1*11, NAT2*5 and NAT2*6 genotypes and risk of head and neck cancer. The NAT2*7 slow genotype was associated with reduced risk of disease. A significant association was observed between the fast acetylator NAT2*4/NAT1*10 diplotype and risk of head and neck cancer. Combined haplotypes harboring the T1088A and C1095A variants characterizing the NAT1*10 allele were associated with increased risk. Our results suggest that NAT1 and NAT2 gene combinations may influence the risk of developing head and neck cancer.
Açıklama
Anahtar Kelimeler
NAT1, NAT2, Genotype, Haplotype, Head and neck cancer
Kaynak
Molecular Biology Reports
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
37
Sayı
7
Künye
Demokan, S., Süoğlu, Y., Gözeler, M., Demir, D. ve Dalay, N. (2010). N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer. Molecular Biology Reports, Springerlink. 37(7), s. 3217-3226.
