N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer

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dc.authorid0000-0001-7914-2201en_US
dc.contributor.authorDemokan, Semra
dc.contributor.authorSüoğlu, Yusufhan
dc.contributor.authorGözeler, Mustafa
dc.contributor.authorDemir, Deniz
dc.contributor.authorDalay, Nejat
dc.contributor.authorDemir, Deniz
dc.date.accessioned2024-07-12T21:00:55Z
dc.date.available2024-07-12T21:00:55Z
dc.date.issued2010en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractPolymorphisms that alter the function of genes involved in the activation or detoxification of carcinogenic compounds can influence an individuals risk of developing cancer. Polymorphic changes modulating the acetylation capacity of the N-acetyltransferase (NAT) genes have been implicated in the risk of developing cancer. In this study the role of genetically determined individual NAT1 and NAT2 genotypes, haplotypes and haplotype combinations in the predisposition to head and neck cancer was investigated. Polymorphic regions of the NAT1 and NAT2 genes were analyzed in patients with head and neck cancer and healthy individuals by polymerase chain reaction-restriction fragment length polymorphism. Distribution of the genotypes, allele frequencies, diplotypes and haplotypes and correlation with clinical characteristics were evaluated. No association was observed between the NAT1*3, NAT1*10, NAT1*11, NAT2*5 and NAT2*6 genotypes and risk of head and neck cancer. The NAT2*7 slow genotype was associated with reduced risk of disease. A significant association was observed between the fast acetylator NAT2*4/NAT1*10 diplotype and risk of head and neck cancer. Combined haplotypes harboring the T1088A and C1095A variants characterizing the NAT1*10 allele were associated with increased risk. Our results suggest that NAT1 and NAT2 gene combinations may influence the risk of developing head and neck cancer.en_US
dc.identifier.citationDemokan, S., Süoğlu, Y., Gözeler, M., Demir, D. ve Dalay, N. (2010). N-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck cancer. Molecular Biology Reports, Springerlink. 37(7), s. 3217-3226.en_US
dc.identifier.endpage3226en_US
dc.identifier.issn1573-4978
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage3217en_US
dc.identifier.urihttps://link.springer.com/article/10.1007/s11033-009-9905-8
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3431
dc.identifier.volume37en_US
dc.institutionauthorDemir, Deniz
dc.language.isoenen_US
dc.publisherSpringerlinken_US
dc.relation.ispartofMolecular Biology Reportsen_US
dc.relation.isversionof10.1007/s11033-009-9905-8en_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY02984
dc.subjectNAT1en_US
dc.subjectNAT2en_US
dc.subjectGenotypeen_US
dc.subjectHaplotypeen_US
dc.subjectHead and neck canceren_US
dc.titleN-acetyltransferase 1 and 2 gene sequence variants and risk of head and neck canceren_US
dc.typeArticle
dspace.entity.typePublication

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