Immune modulation and its role in antiaging

Life expectancy of the communities is constantly increasing every minute, including less developed countries. That’s why application of studies to overcome and/or slow aging has always been an important and attractive issue for professional healthcare workers throughout history. There are numerous studies on different theories for explaining the aging process, but none of them can fully explain the cause. As it is known already, aging of different organs differs in a large extent. Fundamentals of this difference are mitotic activity of the tissues and resistance degree to deleterious damages. Cellular and molecular defense mechanisms clearly define resistance degree as “immunity.” Decline in immunity may cause a progressive step in aging. Inflammaging, which is low-grade chronic inflammatory status that is characteristic of the aging process, can be taught to be a biological factor responsible for the age-related diseases in the elderly. Possibility to decrease inflammaging without compromising the physiological role of inflammation can be a strategy for future perspectives. In this chapter we will focus on aging and immune system regulation together with therapies and/or modulations to rehabilitate aging.