Ondansetron administration before transoesophageal echocardiography reduces the need for sedation and improves patient comfort during the procedure

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dc.authorid0000-0001-6945-0745en_US
dc.contributor.authorAydin, Alper
dc.contributor.authorYilmazer, Mustafa Serdar
dc.contributor.authorGurol, Tayfun
dc.contributor.authorCelik, Omer
dc.contributor.authorDagdeviren, Bahadir
dc.date.accessioned2024-07-12T21:46:31Z
dc.date.available2024-07-12T21:46:31Z
dc.date.issued2010en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractTransoesophageal echocardiography (TEE) is an uncomfortable procedure for the majority of patients. In the current double-blind randomized prospective study, we sought to assess whether ondansetron would improve patient comfort, reduce the need for sedation, and increase tolerance during TEE, and we compared ondansetron, metoclopramide, and placebo. One hundred and fifty-six patients who underwent TEE were randomized into three groups receiving ondansetron HCl, metoclopramide, or placebo. Data concerning additional doses of midazolam, procedural time, recovery time in the outpatient ward, blood pressure values, percutaneous arterial oxygen saturation values, side effects of the medications used, and patient discomfort via a visual analogue scale (VAS) were collected and analysed. The ondansetron group received less additional midazolam than the metoclopramide and placebo groups (ondansetron group: 0.6 +/- 0.7 mg; metoclopramide group: 1.9 +/- 0.9 mg; and placebo group: 2.1 +/- 0.8 mg; P < 0,001). VAS was significantly lower in the ondansetron group than in the metoclopramide and placebo groups (4.0 +/- 1.6, 6.1 +/- 1.8, and 6.6 +/- 1.6, respectively; P < 0.001). Recovery time in the outpatient ward was shorter in the ondansetron group than in the metoclopramide and placebo groups (22.5 +/- 4.8, 30.9 +/- 6.6, and 30.4 +/- 5.0 min, respectively; P < 0.001). No adverse reaction to ondansetron was observed, whereas one patient developed mild spontaneously resolving dystonia due to metoclopramide. Ondansetron administration reduces the need for sedation during TEE and improves patient comfort.en_US
dc.identifier.doi10.1093/ejechocard/jeq061
dc.identifier.endpage755en_US
dc.identifier.issn1525-2167
dc.identifier.issue9en_US
dc.identifier.pmid20472916en_US
dc.identifier.scopus2-s2.0-77958011336en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage752en_US
dc.identifier.urihttps://dx.doi.org/10.1093/ejechocard/jeq061
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7941
dc.identifier.volume11en_US
dc.identifier.wosWOS:000282750900011en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.relation.ispartofEUROPEAN JOURNAL OF ECHOCARDIOGRAPHYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00846
dc.subjectTransoesophageal echocardiographyen_US
dc.subjectPremedicationen_US
dc.subjectOndansetronen_US
dc.subjectAntiemeticsen_US
dc.titleOndansetron administration before transoesophageal echocardiography reduces the need for sedation and improves patient comfort during the procedureen_US
dc.typeArticle
dspace.entity.typePublication

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