The effect of peripheral blood eosinophilia on inflammatory markers in asthmatic patients with lower respiratory tract infections

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dc.authorid0000-0002-3855-7280en_US
dc.authorid0000-0001-7785-7772en_US
dc.contributor.authorCag, Yakup
dc.contributor.authorPacal, Yakup
dc.contributor.authorGunduz, Mehmet
dc.contributor.authorIsik, Sakine
dc.contributor.authorKertmen, Birgul Altinsoy
dc.contributor.authorToprak, Necmettin
dc.contributor.authorOzaydin, Sadik Erhan
dc.contributor.authorOzcetin, Mustafa
dc.contributor.authorKut, Arif
dc.date.accessioned2024-07-12T21:50:48Z
dc.date.available2024-07-12T21:50:48Z
dc.date.issued2019en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground To investigate the behaviour of the inflammatory marker neutrophil-to-lymphocyte ratio (NLR) in the presence of peripheral blood eosinophilia (PBE) in paediatric asthma patients with lower respiratory tract (LRT) infections. Methods This retrospective study enrolled consecutive patients aged >= 5 years who were diagnosed with asthma and whose haemogram values were available. The patients were further subdivided based on the presence or absence of LRT infections and allergies. NLR and C-reactive protein (CRP) were evaluated in relation to the presence or absence of PBE (>= 4% eosinophils). Results A total of 991 patients were enrolled in the study. Patients with LRT infections had significantly higher leucocyte and neutrophil counts, a greater NLR and a higher level of CRP compared with patients without LRT infections. Overall, patients with PBE had significantly lower NLRs and CRP regardless of the presence or absence of an LRT infection. The PBE percentage showed moderate inverse correlations with NLR (r = -0.34) and CRP (r = -0.20). Conclusion The presence of PBE was significantly associated with lower NLR and CRP regardless of the presence or absence of an infectious condition.en_US
dc.identifier.doi10.1177/0300060519844859
dc.identifier.endpage2460en_US
dc.identifier.issn0300-0605
dc.identifier.issn1473-2300
dc.identifier.issue6en_US
dc.identifier.pmid31006357en_US
dc.identifier.scopus2-s2.0-85067173866en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage2452en_US
dc.identifier.urihttps://dx.doi.org/10.1177/0300060519844859
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8206
dc.identifier.volume47en_US
dc.identifier.wosWOS:000471695200014en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofJOURNAL OF INTERNATIONAL MEDICAL RESEARCHen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY01930
dc.subjectLower respiratory tract infectionen_US
dc.subjectperipheral blood eosinophiliaen_US
dc.subjectallergic asthmaen_US
dc.subjectneutrophil-to-lymphocyte ratioen_US
dc.titleThe effect of peripheral blood eosinophilia on inflammatory markers in asthmatic patients with lower respiratory tract infectionsen_US
dc.typeArticle
dspace.entity.typePublication

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