A carboxylated nanodiamond reduces oxidative stress and shows no sign of toxicity in yeast

Basit Öğe Kaydı
dc.authoridThomas, Pınar Buket/0000-0001-7627-0291en_US
dc.contributor.authorKaluc, Nur
dc.contributor.authorThomas, Pınar Buket
dc.date.accessioned2024-07-12T21:37:57Z
dc.date.available2024-07-12T21:37:57Z
dc.date.issued2022en_US
dc.department[Belirlenecek]en_US
dc.description.abstractNanodiamonds (NDs) offer numerous advantages in nanotechnology owing to their unique physicochemical properties. Their chemical stability, natural fluorescence and high absorption capacity make NDs advantageous to be used in many fields including nanomedicine, nano-cosmetics and biomedicine. Recent investigations suggest that NDs can scavenge reactive oxygen species (ROS) therefore act as antioxidants. However, studies regarding the antioxidant properties of NDs are limited and their effects on hydrogen peroxide (H2O2)-induced oxidative stress is not clear. Besides, due to the increased incorporation of cNDs in nanomedical, nano-cosmetics and biomedical products toxicity assessments are needed. Here, we investigated the effects of a carboxylated ND (cND) on H2O2-induced oxidative stress and its 24-hour toxicity in a unicellular eukaryotic model, Saccharomyces cerevisiae. We showed that cND significantly reduces cell death and ROS accumulation in response to H2O2-induced oxidative stress by decreasing H2O2 levels in the media (p < 0.05). Although growth inhibition was observed at higher concentrations (1000 mu g/mL and above, p < 0.05), even 10.000 mu g/mL cND treatment for 24 hours did not completely inhibit colony formation. cND also significantly reduced ROS generated during normal metabolism (p < 0.05) and did not lead to cell death. Our data suggest that cND shows ROS-scavenging activity and has no sign of toxicity in S. cerevisiae.en_US
dc.description.sponsorshipMaltepe University Scientific Research Commisionen_US
dc.description.sponsorshipThis work was supported by Maltepe University Scientific Research Commision.en_US
dc.identifier.doi10.1080/1536383X.2021.1960509
dc.identifier.endpage494en_US
dc.identifier.issn1536-383X
dc.identifier.issn1536-4046
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85111944470en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage487en_US
dc.identifier.urihttps://doi.org/10.1080/1536383X.2021.1960509
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6986
dc.identifier.volume30en_US
dc.identifier.wosWOS:000680315400001en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofFullerenes Nanotubes And Carbon Nanostructuresen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04328
dc.subjectNanodiamonden_US
dc.subjectViabilityen_US
dc.subjectOxidative Stressen_US
dc.subjectRos Scavengeren_US
dc.subjectSaccharomyces Cerevisiaeen_US
dc.titleA carboxylated nanodiamond reduces oxidative stress and shows no sign of toxicity in yeasten_US
dc.typeArticle
dspace.entity.typePublication

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu