Maternal/neonatal vitamin D deficiency: a new risk factor for necrotizing enterocolitis in preterm infants?

dc.authorid0000-0001-8944-0659en_US
dc.contributor.authorCetinkaya, M.
dc.contributor.authorErener-Ercan, T.
dc.contributor.authorKalayci-Oral, T.
dc.contributor.authorBabayigit, A.
dc.contributor.authorCebeci, B.
dc.contributor.authorSemerci, S. Y.
dc.contributor.authorBuyukkale, G.
dc.date.accessioned2024-07-12T21:51:18Z
dc.date.available2024-07-12T21:51:18Z
dc.date.issued2017en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractOBJECTIVE: The objective of the study was to investigate the possible association between maternal/neonatal 25-hydroxy vitamin D (25-OHD) levels and development of necrotizing enterocolitis (NEC). STUDY DESIGN: One hundred and forty-five preterm infants. 36 weeks of gestation were enrolled. 25-OHD levels were determined in maternal/neonatal blood samples that were obtained at the time of admission to the neonatal intensive care unit. RESULTS: Of the 145 enrolled patients, 26 (18%) developed NEC. Maternal/neonatal 25-OHD levels in the NEC group were significantly lower than those of the no-NEC group (P = 0.001 and 0.004, respectively). In univariate logistic regression analysis, both maternal/neonatal vitamin D levels were a significant predictor of NEC (odds ratio (OR): 0.92 and 0.89; P < 0.001 and P < 0.005, respectively). However, multivariate logistic regression analysis revealed that only maternal vitamin D level was a significant predictor of NEC (OR: 0.86, P < 0.0009). CONCLUSION: This is the first study to propose a possible association between maternal/neonatal 25-OHD levels and subsequent development of NEC in preterm infants.en_US
dc.description.sponsorshipChiesi Pharmaceuticals, Turkeyen_US
dc.description.sponsorshipWe thank Chiesi Pharmaceuticals, Turkey for their support in the performance of statistical analysis of this work. Chiesi Pharmaceuticals had no role in the study design, collection, analysis and interpretation of data, writing of the report and in the decision to submit the article for publication.en_US
dc.identifier.doi10.1038/jp.2017.18
dc.identifier.endpage678en_US
dc.identifier.issn0743-8346
dc.identifier.issn1476-5543
dc.identifier.issue6en_US
dc.identifier.pmid28333154en_US
dc.identifier.scopus2-s2.0-85015926151en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage673en_US
dc.identifier.urihttps://dx.doi.org/10.1038/jp.2017.18
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8255
dc.identifier.volume37en_US
dc.identifier.wosWOS:000402295200013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherNATURE PUBLISHING GROUPen_US
dc.relation.ispartofJOURNAL OF PERINATOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY02012
dc.titleMaternal/neonatal vitamin D deficiency: a new risk factor for necrotizing enterocolitis in preterm infants?en_US
dc.typeArticle
dspace.entity.typePublication

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