Use of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practice

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dc.authoridŞahin, Şevki/0000-0003-2016-9965en_US
dc.contributor.authorGüneş, Taşkın
dc.contributor.authorSirin, Nermin Gorkem
dc.contributor.authorŞahin, Şevki
dc.contributor.authorKose, Ercan
dc.contributor.authorIsak, Baris
dc.date.accessioned2024-07-12T21:37:51Z
dc.date.available2024-07-12T21:37:51Z
dc.date.issued2021en_US
dc.department[Belirlenecek]en_US
dc.description.abstractBackground: The pattern of lower motor neuron (LMN) degeneration in amyotrophic lateral sclerosis (ALS), i.e., dying-back (from the nerve ending to cell body) or dying-forward (from the cell body to nerve ending), has been widely discussed. In this study, we aimed to evaluate LMN loss using compound muscle action potential (CMAP), motor unit number index (MUNIX), and MScan-fit-based motor unit number estimation (MUNE) to understand the pattern of neurodegeneration in ALS. Methods: Twenty-five patients were compared with 25 controls using CMAP amplitude and area, MUNIX, and MScan-fit MUNE in three proximal and distal muscles innervated by the ulnar nerve. Results: Unlike the controls, the CMAP area, MScan-fit MUNE, and MUNIX recorded in ALS patients showed more neurodegeneration in distal muscles than proximal muscles. In ALS patients with unaffected CMAP amplitudes (n = 13), the CMAP area, MScan-fit MUNE, and MUNIX showed subtle motor unit loss of 30.7 %, 53.8 %, and 38.4 %, respectively. Conclusion: The CMAP area, MScan-fit MUNE, and MUNIX showed neurodegeneration earlier than the reduction in CMAP amplitude. These tests confirmed dying-back neurodegeneration, while only MUSIX showed re-innervation in ALS.en_US
dc.identifier.doi10.1016/j.neulet.2020.135488
dc.identifier.issn0304-3940
dc.identifier.issn1872-7972
dc.identifier.pmid33217503en_US
dc.identifier.scopus2-s2.0-85096849328en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2020.135488
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6961
dc.identifier.volume741en_US
dc.identifier.wosWOS:000600546900024en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofNeuroscience Lettersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04303
dc.subjectAmyotrophic Lateral Sclerosisen_US
dc.subjectMotor Unit Number Estimationen_US
dc.subjectDenervationen_US
dc.subjectReinnervationen_US
dc.titleUse of CMAP, MScan fit-MUNE, and MUNIX in understanding neurodegeneration pattern of ALS and detection of early motor neuron loss in daily practiceen_US
dc.typeArticle
dspace.entity.typePublication

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