Two different mechanisms of two different non-coding RNAs—MicroRNAs and PIWI-interacting RNAs: From origin to cancer
Küçük Resim Yok
Tarih
2019
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
“Junk DNA” sequences, which are clusters of small non-coding RNAs, were initially considered regions that do not encode protein, but it has been determined that they play important roles in epigenetic mechanisms in cancerous cells, stem cells, and healthy cells. MicroRNAs (miRNAs) are Dicer-dependent and are associated with Argonaute (AGO) proteins for the transcriptional repression or degradation of target mRNA. Another type of small non-coding RNA is PIWI-interacting RNA (piRNA). piRNAs are incorporated with AGO proteins called PIWI proteins and these piRNAs expressions are not related with Dicer. Although piRNAs and PIWIs were thought to play an important role in embryogenesis (especially spermatogenesis) via transposon silencing, recent studies have shown that they also affect cancer development and biology. In this chapter, the background of miRNAs and piRNAs, the biogenesis and functions of these small non-coding RNAs in cells, and their specific expression patterns in several cancer types are discussed.
Açıklama
Anahtar Kelimeler
Argonaute, Cancer, Metastasis, miRNA, PIWI, piRNA
Kaynak
Ago-driven non-coding RNAs : codes to decode the therapeutics of diseases
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Sayı
Künye
Öner, Ç. (2019). Two different mechanisms of two different non-coding RNAs—MicroRNAs and PIWI-interacting RNAs: From origin to cancer. B. Mallick (Ed.), Ago-driven non-coding RNAs : codes to decode the therapeutics of diseases içinde (ss. 3-34). Elsevier.
