Two different mechanisms of two different non-coding RNAs—MicroRNAs and PIWI-interacting RNAs: From origin to cancer

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dc.authorid0000-0003-3771-3277en_US
dc.authorid0000-0003-4311-0720en_US
dc.contributor.authorÖner, Çağrı
dc.contributor.editorMallick, Bibekanand
dc.date.accessioned2024-07-12T20:59:37Z
dc.date.available2024-07-12T20:59:37Z
dc.date.issued2019en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstract“Junk DNA” sequences, which are clusters of small non-coding RNAs, were initially considered regions that do not encode protein, but it has been determined that they play important roles in epigenetic mechanisms in cancerous cells, stem cells, and healthy cells. MicroRNAs (miRNAs) are Dicer-dependent and are associated with Argonaute (AGO) proteins for the transcriptional repression or degradation of target mRNA. Another type of small non-coding RNA is PIWI-interacting RNA (piRNA). piRNAs are incorporated with AGO proteins called PIWI proteins and these piRNAs expressions are not related with Dicer. Although piRNAs and PIWIs were thought to play an important role in embryogenesis (especially spermatogenesis) via transposon silencing, recent studies have shown that they also affect cancer development and biology. In this chapter, the background of miRNAs and piRNAs, the biogenesis and functions of these small non-coding RNAs in cells, and their specific expression patterns in several cancer types are discussed.en_US
dc.identifier.citationÖner, Ç. (2019). Two different mechanisms of two different non-coding RNAs—MicroRNAs and PIWI-interacting RNAs: From origin to cancer. B. Mallick (Ed.), Ago-driven non-coding RNAs : codes to decode the therapeutics of diseases içinde (ss. 3-34). Elsevier.en_US
dc.identifier.endpage34en_US
dc.identifier.isbn978-0-12-815669-8
dc.identifier.startpage3en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/B9780128156698000014
dc.identifier.urihttps://hdl.handle.net/20.500.12415/3322
dc.institutionauthorÖner, Çağrı
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofAgo-driven non-coding RNAs : codes to decode the therapeutics of diseasesen_US
dc.relation.isversionof10.1016/C2017-0-02318-2en_US
dc.relation.publicationcategoryUluslararası Kitapta Bölümen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY05456
dc.subjectArgonauteen_US
dc.subjectCanceren_US
dc.subjectMetastasisen_US
dc.subjectmiRNAen_US
dc.subjectPIWIen_US
dc.subjectpiRNAen_US
dc.titleTwo different mechanisms of two different non-coding RNAs—MicroRNAs and PIWI-interacting RNAs: From origin to canceren_US
dc.typeBook Part
dspace.entity.typePublication

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