Comparative biological network analysis for differentially expressed proteins as a function of bacilysin biosynthesis in Bacillus subtilis

dc.authoridÖzcengiz, Gülay/0000-0002-8628-3202en_US
dc.contributor.authorKutnu, Meltem
dc.contributor.authorIslerel, Elif Tekin
dc.contributor.authorTunçbag, Nurcan
dc.contributor.authorÖzcengiz, Gülay
dc.date.accessioned2024-07-12T21:37:44Z
dc.date.available2024-07-12T21:37:44Z
dc.date.issued2022en_US
dc.department[Belirlenecek]en_US
dc.description.abstractThe Gram-positive bacterium Bacillus subtilis produces a diverse range of secondary metabolites with different structures and activities. Among them, bacilysin is an enzymatically synthesized dipeptide that consists of L-alanine and L-anticapsin. Previous research by our group has suggested bacilysin's role as a pleiotropic molecule in its producer, B. subtilis PY79. However, the nature of protein interactions in the absence of bacilysin has not been defined. In the present work, we constructed a protein-protein interaction subnetwork by using Omics Integrator based on our recent comparative proteomics data obtained from a bacilysin-silenced strain, OGU1. Functional enrichment analyses on the resulting networks pointed to certain putatively perturbed pathways such as citrate cycle, quorum sensing and secondary metabolite biosynthesis. Various molecules, which were absent from the experimental data, were included in the final network. We believe that this study can guide further experiments in the identification and confirmation of protein-protein interactions in B. subtilis.en_US
dc.identifier.doi10.1093/intbio/zyac010
dc.identifier.endpage110en_US
dc.identifier.issn1757-9694
dc.identifier.issn1757-9708
dc.identifier.issue5en_US
dc.identifier.pmid35901454en_US
dc.identifier.scopus2-s2.0-85135597270en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage99en_US
dc.identifier.urihttps://doi.org/10.1093/intbio/zyac010
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6910
dc.identifier.volume14en_US
dc.identifier.wosWOS:000834329000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.relation.ispartofIntegrative Biologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04252
dc.subjectBacillus Subtilisen_US
dc.subjectBacilysinen_US
dc.subjectProteomicsen_US
dc.subjectNetwork Modelingen_US
dc.subjectClusteringen_US
dc.subjectPathway Analysisen_US
dc.titleComparative biological network analysis for differentially expressed proteins as a function of bacilysin biosynthesis in Bacillus subtilisen_US
dc.typeArticle
dspace.entity.typePublication

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