Prognostic impact of the metastatic lymph node ratio on survival in rectal cancer

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dc.contributor.authorAttaallah W.
dc.contributor.authorGunal O.
dc.contributor.authorManukyan, Manuk Norayık
dc.contributor.authorOzden G.
dc.contributor.authorYegen C.
dc.date.accessioned2024-07-12T21:45:00Z
dc.date.available2024-07-12T21:45:00Z
dc.date.issued2013en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractPurpose: Lymph-node metastasis is the most important predictor of survival in stage III rectal cancer. The number of metastatic lymph nodes may vary depending on the level of specimen dissection and the total number of lymph nodes harvested. The aim of this study was to evaluate whether the lymph node ratio (LNR) is a prognostic parameter for patients with rectal cancer. Methods: A retrospective review of a database of rectal cancer patients was performed to determine the effect of the LNR on the disease-free survival (DFS) and the overall survival. Of the total 228 patients with rectal cancer, 55 patients with stage III cancer were eligible for analysis. Survival curves were estimated using the Kaplan-Meier method. Cox regression analyses, after adjustments for potential confounders, were used to evaluate the relationship between the LNR and survival. Results: According to the cutoff point 0.15 (15%), the 2-year DFS was 95.2% among patients with a LNR < 0.15 compared with 67.6% for those with LNR ? 0.15 (P = 0.02). In stratified and multivariate analyses adjusted for age, gender, histology and tumor status, a higher LNR was independently associated with worse DFS. Conclusion: This study showed the prognostic significance of ratio-based staging for rectal cancer and may help in developing better staging systems. LNR 0.15 (15%) was shown to be a cutoff point for determining survival and prognosis in rectal cancer cases. © 2013 The Korean Society of Coloproctology.en_US
dc.identifier.doi10.3393/ac.2013.29.3.100
dc.identifier.endpage105en_US
dc.identifier.issn2287-9714
dc.identifier.issue3en_US
dc.identifier.pmid23862127en_US
dc.identifier.scopus2-s2.0-84885944591en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage100en_US
dc.identifier.urihttps://dx.doi.org/10.3393/ac.2013.29.3.100
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7769
dc.identifier.volume29en_US
dc.identifier.wosWOS:000441667500005en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofAnnals of Coloproctologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00260
dc.subjectLymph nodesen_US
dc.subjectPrognosisen_US
dc.subjectRectal neoplasmsen_US
dc.subjectSurvivalen_US
dc.titlePrognostic impact of the metastatic lymph node ratio on survival in rectal canceren_US
dc.typeArticle
dspace.entity.typePublication

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