NO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish population

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dc.contributor.authorAfrasyap, L
dc.contributor.authorOzturk, G
dc.date.accessioned2024-07-12T21:44:12Z
dc.date.available2024-07-12T21:44:12Z
dc.date.issued2004en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractNitric oxide is synthesized from L-arginine by endothelial nitric oxide synthase encoded by eNOS gene. This study was performed to investigate the relationship between the serum nitric oxide level and eNOS gene polymorphism in the Turkish population with angiographically diagnosed coronary artery disease (63.47 +/- 9.10 years old, n=250) and control subjects without any history and/or risk factors of coronary artery disease (60.71 +/- 9.14 years old, n=150). Griess assay and PCR-RFLP analysis were used to measure the serum nitric oxide metabolites and genotypes, respectively. It was found that Glu/Glu, Glu/Asp and Asp/Asp genotype frequencies of the eNOS were 49.3%, 41.3% and 9.3% respectively in the control group, and 45.6%, 41.2% and 13.2% in the patient group. Serum nitric oxide levels were (32.56 +/- 17.26) muM in controls and (29.84 +/- 11.88) muM in patients. Neither the frequencies of the Glu298Asp genotypes nor the serum nitric oxide levels showed a significant difference between the groups. There was also no correlation between serum nitric oxide levels and the frequencies of the eNOS genotypes. Result showed that the coronary artery disease of the Turkish population seemed to develop without any alterations in eNOS Glu298Asp genotype frequency and the serum nitric oxide level.en_US
dc.identifier.doi10.1093/abbs/36.10.661
dc.identifier.endpage666en_US
dc.identifier.issn1672-9145
dc.identifier.issn1745-7270
dc.identifier.issue10en_US
dc.identifier.pmid15483745en_US
dc.identifier.scopus2-s2.0-10044280657en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage661en_US
dc.identifier.urihttps://dx.doi.org/10.1093/abbs/36.10.661
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7694
dc.identifier.volume36en_US
dc.identifier.wosWOS:000224758500003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherOXFORD UNIV PRESSen_US
dc.relation.ispartofACTA BIOCHIMICA ET BIOPHYSICA SINICAen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00022
dc.subjectcoronary artery diseaseen_US
dc.subjectgeneticsen_US
dc.subjectnitric oxideen_US
dc.subjectpolymorphismen_US
dc.subjectpopulationen_US
dc.titleNO level and endothelial NO synthase gene polymorphism (Glu298Asp) in the patients with coronary artery disease from the Turkish populationen_US
dc.typeArticle
dspace.entity.typePublication

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