Changing clinical characteristics of non-cystic fibrosis bronchiectasis in children

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dc.contributor.authorEralp, Ela Erdem
dc.contributor.authorGökdemir, Yasemin
dc.contributor.authorEtag, Emine
dc.contributor.authorİkizoğlu, Nilay Baş
dc.contributor.authorErgenekon, Pınar
dc.contributor.authorYegit, Cansu Yılmaz
dc.contributor.authorKurt, Arif
dc.contributor.authorErsu, Refika
dc.contributor.authorKarakoç, Fazilet
dc.contributor.authorKaradağ, Bülent
dc.date.accessioned2024-07-12T21:43:21Z
dc.date.available2024-07-12T21:43:21Z
dc.date.issued2020en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground The prevalence of non-cystic fibrosis (CF) bronchiectasis is increasing in both developed and developing countries in recent years. Although the main features remain similar, etiologies seem to change. Our aim was to evaluate the clinical and laboratory characteristics of our recent non-CF bronchiectasis patients and to compare these with our historical cohort in 2001. Methods One hundred four children with non-CF bronchiectasis followed between 2002 and 2019 were enrolled. Age of diagnosis, underlying etiology and microorganisms in sputum culture were recorded. Clinical outcomes were evaluated in terms of lung function tests and annual pulmonary exacerbation rates at presentation and within the last 12 months. Results Mean FEV1 and FVC %predicted at presentation improved compared to historical cohort (76.6 +/- 17.1 vs. 63.3 +/- 22.1 and 76.6 +/- 15.1 vs. 67.3 +/- 23.1, respectively;p < 0.001). There was a significant decrease in pulmonary exacerbation rate from 6.05 +/- 2.88 at presentation to 3.23 +/- 2.08 during follow-up (p < 0.0001). In 80.8% of patients, an underlying etiology was identified. There was an increase in primary ciliary dyskinesia (PCD) (32.7% vs. 6.3%;p = 0.001), decrease in idiopathic cases (19.2% vs. 37.8%;p = 0.03) with no change in postinfectious and immunodeficiencies as underlying etiology. Sputum cultures were positive in 77.9% of patients which was 46.9% in the historical cohort (p = 0.001). Conclusion Baseline pulmonary function tests were better and distribution of underlying etiology had changed with a remarkable increase in diagnosis of PCD in the recent cohort.en_US
dc.identifier.citationEralp, E. E., Gökdemir, Y., Atag, E., İkizoğlu, N. B., Ergenekon, P., Yegit, C. Y., Kut, A., Ersu, R., Karakoç, F. ve Karadağ, B. (2020). Changing clinical characteristics of non-cystic fibrosis bronchiectasis in children. BMC Pulmonary Medicine. 20(1).en_US
dc.identifier.doi10.1186/s12890-020-01214-7
dc.identifier.issue1en_US
dc.identifier.pmid32546272en_US
dc.identifier.scopus2-s2.0-85086686567en_US
dc.identifier.urihttps://doi.prg/10.1186/s12890-020-01214-7
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7586
dc.identifier.volume20en_US
dc.identifier.wosWOS:000542726200002en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherBMCen_US
dc.relation.ispartofBMC Pulmonary Medicineen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY00440
dc.subjectSuppurative lung-diseaseen_US
dc.subjectNon-cf bronchiectasisen_US
dc.subjectEtiologyen_US
dc.subjectPopulationen_US
dc.subjectProfileen_US
dc.titleChanging clinical characteristics of non-cystic fibrosis bronchiectasis in childrenen_US
dc.typeArticle
dspace.entity.typePublication

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