Thymoma and limbic encephalitis: a dangerous liaison

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dc.authorid0000-0001-5953-4240en_US
dc.authorid0000-0003-2016-9965en_US
dc.authorid0000-0003-3868-3137en_US
dc.authorid0000-0001-5974-458Xen_US
dc.authorid0000-0002-2887-9235en_US
dc.contributor.authorAteş, Miruna Florentina
dc.contributor.authorŞahin, Şevki
dc.contributor.authorÇınar, Nilgün
dc.contributor.authorBozdemir, Meral
dc.contributor.authorKarşıdağ, Sibel
dc.date.accessioned2024-07-12T21:11:01Z
dc.date.available2024-07-12T21:11:01Z
dc.date.issued2018en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractTo the Editor: Limbic encephalitis may have various causes and be associated with a number of neuropsychiatric disorders.1 Our knowledge of viral etiology, including herpes simplex virus, is quite advanced, but in autoimmune cases, our knowledge is still limited. A 72-year-old man was admitted to our outpatient clinic for sudden-onset amnesia and confusion that had lasted for more than 2 weeks. The symptoms manifested 15 days previously as a result of a psychologically stressful situation, and he was unable to find his way home. According to relatives, he had been staring at a fixed point for 2 minutes at a time and had a conversation with his deceased mother. These episodes were repeated several times during the same day. His medical history included mild heart failure and benign prostatic hyperplasia. He had been treated with indapamide, acetylsalicylic acid, and alfuzosin for hypertension and benign prostate hypertrophy. During the neurologic examination, his personal and place orientation were found to be normal despite temporal disorientation. His speech included word perseverations. His standardized Mini-Mental State Examination (MMSE)3 score was 21/30 (2 points lost for orientation, 3 for attention and calculation, 2 for recall, and 2 for language). Perseverations in Luria alternating motor sequences and clock drawing tests and planning errors were also present, suggesting executive dysfunction and mild cognitive impairment. Results of the examination of pyramidal, extrapyramidal, cerebellar, and sensory systems were found to be within normal limits. Brain magnetic resonance imaging (MRI) revealed hyperintensities in bilateral mesial temporal lobes (Figure 1). His electroencephalogram showed bitemporal neuronal hyperexcitability. No fever was present, and blood chemistry analysis including blood count was unremarkable. Cerebrospinal fluid (CSF) analysis showed protein and glucose levels within normal limits with no inflammatory cells. Herpes simplex virus 1 and 2 IgG and IgM antibodies examined by the polymerase chain reaction test were negative. The diagnosis was limbic encephalitis associated with cognitive impairment and epilepsy. The patient was given intravenous prednisolone 1,000 mg/d for 5 days followed by oral prednisolone at a dose of 16 mg per/d. In addition, valproic acid 1,000 mg/d was started orally. The limbic encephalitis antibody panel of plasma and CSF showed leucine-rich glioma inactivated 1 (LGI1) positivity. Abdomen and thorax computed tomography (CT) scans were performed. A round mass lesion was found in the retrosternal area on the thorax CT scan. Examination results of acetylcholine receptor antibodies and muscle-specific tyrosine kinase in peripheral blood were negative. An anterior thoracotomy was performed, and the mediastinal mass was removed. The pathological examination showed type B2 thymoma (cortical thymoma).Our final diagnosis established anti-LGI1 limbic encephalitis related to thymoma according to the 2018 ICD-10-CM diagnosis code G04.81 (other encephalitis-limbic). Oral prednisolone was discontinued because a second brain MRI showed regression in lesions 6 weeks after surgery. At the 6-month follow-up visit, the patient showed none of the previous symptoms and was given no immune treatment. His MMSE score had improved to 25/30 (2 points lost for attention and calculation, 1 for recall, and 2 for language). His score improved due to better orientation and recall. Valproic acid was prescribed to be used for at least 1 year. LGI1 is a secreted synaptic protein that organizes ?-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors of glutamate.4 LGI1 antibodies are associated with thymoma in a ratio < 5% and even less with other cancers. Anti-LGI1 limbic encephalitis can cause memory dysfunction and seizures. In this disorder, the most affected brain area is the medial temporal lobe. In addition, hyponatremia is common in these cases.5 Thymomas are commonly associated with myasthenia gravis.6 However, this case highlights that thymomas may also be related to limbic encephalitis.en_US
dc.identifier.citationAteş, M.F., Şahin, Ş. vd. (2018). Thymoma and limbic encephalitis: a dangerous liaison. Primary Care Companion for CNS Disorders, Physicians Postgraduate Press. 20(5).en_US
dc.identifier.doi10.4088/PCC.17l02257
dc.identifier.issn2155-7780
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-85054062955en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://www.psychiatrist.com/pcc/mental/thymoma-and-limbic-encephalitis-a-dangerous-liaison/
dc.identifier.urihttps://doi.prg/10.4088/PCC.17l02257
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4314
dc.identifier.volume20en_US
dc.indekslendigikaynakScopus
dc.institutionauthorAteş, Miruna Florentina
dc.institutionauthorŞahin, Şevki
dc.institutionauthorÇınar, Nilgün
dc.institutionauthorBozdemir, Meral
dc.institutionauthorKarşıdağ, Sibel
dc.language.isoenen_US
dc.publisherPhysicians Postgraduate Pressen_US
dc.relation.ispartofPrimary Care Companion for CNS Disordersen_US
dc.relation.publicationcategoryUluslararası Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03301
dc.titleThymoma and limbic encephalitis: a dangerous liaisonen_US
dc.typeArticle
dspace.entity.typePublication

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