Insulin Resistance and Metabolic Syndrome in Patients with Seborrheic Dermatitis: A Case-Control Study

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dc.authoridSavas Erdoğan, Sevil/0000-0002-4392-4671en_US
dc.contributor.authorSavas Erdoğan, Sevil
dc.contributor.authorFalay Gur, Tuğba
dc.contributor.authorÖzkur, Ezgi
dc.contributor.authorDogan, Bilal
dc.date.accessioned2024-07-12T21:37:48Z
dc.date.available2024-07-12T21:37:48Z
dc.date.issued2022en_US
dc.department[Belirlenecek]en_US
dc.description.abstractBackground: Our knowledge of the systemic effects of seborrheic dermatitis (SD) as a chronic inflammatory skin disease remains limited. We aimed to evaluate metabolic syndrome (MS) and glucose metabolism disorders in patients with SD. Methods: The study includes 53 patients over the age of 18 diagnosed with SD and 50 age-, gender-, and body mass index-matched healthy controls. Demographic data, anthropometric measurements, blood pressure levels, family history of SD and metabolic disorder, smoking history, and severity of the disease in SD patients were obtained. Fasting plasma glucose, insulin, hemoglobin A1c, lipid profile levels, and two-hour plasma glucose in the oral glucose tolerance test (OGTT 2-h PG), homeostasis model assessment of insulin resistance (HOMA-IR), and presence of MS were determined. Results: Weight, waist circumference, family history of SD, family history of metabolic disorder, and smoking status were significantly higher in the SD group compared with the control group (P = 0.04, P = 0.007, P = 0.004, P = 0.004, and P = 0.048, respectively). The levels of fasting plasma insulin and triglyceride, HOMA-IR and OGTT 2-h PG were also significantly higher in the SD group than in the control group (P = 0.0001, P = 0.033, P = 0.0001, and P = 0.049, respectively). In addition, the number of those with insulin resistance was significantly higher in the group with SD (n = 31, 58.49%) than in the control group (n = 11, 22%) (P = 0.0001). Although the rate of MS was higher in patients with SD (n = 12, 22.64%) than the controls (n = 6, 12%), the difference was not significant (P = 0.155). Conclusion: Our findings suggest an association between SD and insulin resistance, which may be due to their common inflammatory pathogenesis. This may be an indicator of susceptibility to diabetes, and these patients can be followed up for conditions associated with insulin resistance and encouraged to adopt a healthy lifestyle.en_US
dc.identifier.doi10.1089/met.2021.0063
dc.identifier.endpage56en_US
dc.identifier.issn1540-4196
dc.identifier.issn1557-8518
dc.identifier.issue1en_US
dc.identifier.pmid34698561en_US
dc.identifier.scopus2-s2.0-85125001020en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage50en_US
dc.identifier.urihttps://doi.org/10.1089/met.2021.0063
dc.identifier.urihttps://hdl.handle.net/20.500.12415/6945
dc.identifier.volume20en_US
dc.identifier.wosWOS:000713248000001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherMary Ann Liebert, Incen_US
dc.relation.ispartofMetabolic Syndrome And Related Disordersen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY04287
dc.subjectHoma-Iren_US
dc.subjectGlucose Intoleranceen_US
dc.subjectInsulin Resistanceen_US
dc.subjectMetabolic Syndromeen_US
dc.subjectSeborrheic Dermatitisen_US
dc.titleInsulin Resistance and Metabolic Syndrome in Patients with Seborrheic Dermatitis: A Case-Control Studyen_US
dc.typeArticle
dspace.entity.typePublication

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