Neurophysiological and morphological responses to treatment with acetyl-L-carnitine in a sciatic nerve injury model: preliminary data

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dc.authorid0000-0003-2016-9965en_US
dc.authorid0000-0003-2016-996en_US
dc.authorid0000-0002-1234-9029en_US
dc.authorid0000-0002-2887-9235en_US
dc.contributor.authorKarsidag, S.
dc.contributor.authorAkcal, A.
dc.contributor.authorSahin, S.
dc.contributor.authorKarsidag, S.
dc.contributor.authorKabukcuoglu, F.
dc.contributor.authorUgurlu, K.
dc.date.accessioned2024-07-12T21:50:45Z
dc.date.available2024-07-12T21:50:45Z
dc.date.issued2012en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractWe investigated the effects of acetyl-L-carnitine (ALCAR) on the recovery of sciatic nerve injuries in rats. Sprague Dawley rats were randomized to two groups: ALCAR treated (for 14 days) and control. Each group was divided into three subgroups: distal transection, proximal transection, and grafted. Distal latencies, amplitudes, and motor nerve conduction velocities were measured. In the third month, biopsies were taken and examined under light microscopy. Electrophysiological measurements demonstrated that regeneration occurred earlier and was better in the ALCAR group, particularly in the distal transection subgroup. Better results were obtained in the distal transection subgroup in terms of axonal regeneration compared with the proximal transection and grafted subgroups because the regenerating segment was shorter. ALCAR enhanced the quality of neural recovery at the different levels and in different types of repair, and led to a decline in nerve death.en_US
dc.identifier.doi10.1177/1753193411426969
dc.identifier.endpage536en_US
dc.identifier.issn1753-1934
dc.identifier.issue6en_US
dc.identifier.pmid22080531en_US
dc.identifier.scopus2-s2.0-84863187722en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage529en_US
dc.identifier.urihttps://dx.doi.org/10.1177/1753193411426969
dc.identifier.urihttps://hdl.handle.net/20.500.12415/8198
dc.identifier.volume37Een_US
dc.identifier.wosWOS:000305838800009en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSAGE PUBLICATIONS LTDen_US
dc.relation.ispartofJOURNAL OF HAND SURGERY-EUROPEAN VOLUMEen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY01908
dc.subjectAcetyl-L-carnitineen_US
dc.subjectCMAP distal latencyen_US
dc.subjectCMAP amplitudeen_US
dc.subjectconduction velocityen_US
dc.titleNeurophysiological and morphological responses to treatment with acetyl-L-carnitine in a sciatic nerve injury model: preliminary dataen_US
dc.typeArticle
dspace.entity.typePublication

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