The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer
Küçük Resim Yok
Tarih
2006
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
National Center for Biotechnology Information
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Detection of micrometastatic disease is an interesting area in non-small cell lung cancer (NSCLC). We conducted a study to determine whether the detection of mediastinal lymph node spread by immunohistochemical (IHC) analysis offers some prognosis with respect to patients' disease-free survival or not. Methods: Between 1997 and 2003, twenty-one early stage lung cancer patients underwent complete resection with mediastinoscopy and systemic nodal dissection. Four hundred and twenty-six paraffin-embedded lymph node sections from 21 patients were analyzed. Epithelial specific-antigen Ab-9 and Keratin-Pan Ab-1 were used as IHC marker. Results: Based on nodal spread four of the 21 patients (19.04%) were up-staged after IHC analysis. Two patients with stage IB (T2N0) up-staged to stage IIIA (T2N2); two patients staged as IIB (T2N1) up-staged to IIIA (T2N2). Statistical analysis showed that the lymphatic dissemination detected with IHC analysis was associated with reduced disease-free survival (DFS) (p = 0.002). Conclusions: Our study provides some indication that patients with lymphatic micrometastasis have a reduced DFS. Before creating a new TNM staging system, more information is needed to understand the prognostic impact of micrometastatic dissemination.
Açıklama
Anahtar Kelimeler
Kaynak
The Thoracic and Cardiovascular Surgeon
WoS Q Değeri
Scopus Q Değeri
Cilt
54
Sayı
2
Künye
Tezel, C., Ersev, A. A., Kiral, H., Ürek, S., Koşar, A., Dudu, C. ve Arman, B. (2006). The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer. The Thoracic and Cardiovascular Surgeon. 54(2), s. 124-128.
