The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer

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dc.authorid0000-0001-9169-560Xen_US
dc.contributor.authorTezel, Çağatay
dc.contributor.authorErsev, Ayşe Alp
dc.contributor.authorKiral, Hakan
dc.contributor.authorKoşar, Altuğ
dc.contributor.authorKeleş, Murat
dc.contributor.authorDudu, Canan
dc.contributor.authorArman, Bülent
dc.date.accessioned2024-07-12T21:11:46Z
dc.date.available2024-07-12T21:11:46Z
dc.date.issued2006en_US
dc.departmentFakülteler, Tıp Fakültesien_US
dc.description.abstractBackground: Detection of micrometastatic disease is an interesting area in non-small cell lung cancer (NSCLC). We conducted a study to determine whether the detection of mediastinal lymph node spread by immunohistochemical (IHC) analysis offers some prognosis with respect to patients' disease-free survival or not. Methods: Between 1997 and 2003, twenty-one early stage lung cancer patients underwent complete resection with mediastinoscopy and systemic nodal dissection. Four hundred and twenty-six paraffin-embedded lymph node sections from 21 patients were analyzed. Epithelial specific-antigen Ab-9 and Keratin-Pan Ab-1 were used as IHC marker. Results: Based on nodal spread four of the 21 patients (19.04%) were up-staged after IHC analysis. Two patients with stage IB (T2N0) up-staged to stage IIIA (T2N2); two patients staged as IIB (T2N1) up-staged to IIIA (T2N2). Statistical analysis showed that the lymphatic dissemination detected with IHC analysis was associated with reduced disease-free survival (DFS) (p = 0.002). Conclusions: Our study provides some indication that patients with lymphatic micrometastasis have a reduced DFS. Before creating a new TNM staging system, more information is needed to understand the prognostic impact of micrometastatic dissemination.en_US
dc.identifier.citationTezel, C., Ersev, A. A., Kiral, H., Ürek, S., Koşar, A., Dudu, C. ve Arman, B. (2006). The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer. The Thoracic and Cardiovascular Surgeon. 54(2), s. 124-128.en_US
dc.identifier.endpage128en_US
dc.identifier.issue2en_US
dc.identifier.startpage124en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/16541355/
dc.identifier.urihttps://hdl.handle.net/20.500.12415/4395
dc.identifier.volume54en_US
dc.institutionauthorKoşar, Altuğ
dc.language.isoenen_US
dc.publisherNational Center for Biotechnology Informationen_US
dc.relation.ispartofThe Thoracic and Cardiovascular Surgeonen_US
dc.relation.isversionof10.1055/s-2005-872867en_US
dc.relation.publicationcategoryUlusal Hakemli Dergide Makale - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.snmzKY03573
dc.titleThe impact of immunohistochemical detection of positive lymph nodes in early stage lung canceren_US
dc.typeArticle
dspace.entity.typePublication

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