Mucociliary transport and histopathological changes in rotation flaps of the nasal mucosa

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dc.contributor.authorAtespare, Altay
dc.contributor.authorUstundag, Emre
dc.contributor.authorDalcik, Hakki
dc.contributor.authorCelik, Oner
dc.date.accessioned2024-07-12T21:46:28Z
dc.date.available2024-07-12T21:46:28Z
dc.date.issued2015en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractNormal mucociliary transport in the mucoperichondrium of the nasal septum is from a distal (anterior) to proximal (posterior) direction. This study was to determine the direction of mucociliary transport and histopathological changes in nasal mucosal rotation flaps when their transport directions were anatomically reversed. Thirty-two rabbits were divided into four groups. Surgical septal rotational flaps were prepared in the experimental groups. Group I was the control group. The distal aspect of the flap was sutured through a large septal window to the other side of the nasal septum, thus changing the direction of the flap. Evaluation was performed 1 week, 1 month and 9 months later with each of these groups named as groups II, III, and IV, respectively. The rate and direction of the mucociliary transport was determined and histopathological investigations were performed from the flaps. The direction of mucociliary transport was observed to continue as distal to proximal direction in the rotated segments. The mucociliary transport rate was found to be decreased in group II, nearly normal in group III, and in normal limits in group IV after surgery. Intense inflammation and decreased number of cilia were present in group II. The inflammation was milder in group III and the epithelium was found to be nearly normal in group IV. The originally programmed direction of mucociliary transport in the nasal rotation flaps is maintained and is not altered or reprogrammed. Histopathological changes revert back to normal from an inflammatory state to reach pre-surgical status over time.en_US
dc.identifier.doi10.1007/s00405-014-3183-3
dc.identifier.endpage1148en_US
dc.identifier.issn0937-4477
dc.identifier.issn1434-4726
dc.identifier.issue5en_US
dc.identifier.pmid25022717en_US
dc.identifier.scopus2-s2.0-84928563987en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1143en_US
dc.identifier.urihttps://dx.doi.org/10.1007/s00405-014-3183-3
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7936
dc.identifier.volume272en_US
dc.identifier.wosWOS:000351698300013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSPRINGERen_US
dc.relation.ispartofEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGYen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00835
dc.subjectNasal mucosaen_US
dc.subjectMucociliary transporten_US
dc.subjectMucociliary clearanceen_US
dc.subjectMucosal regenerationen_US
dc.titleMucociliary transport and histopathological changes in rotation flaps of the nasal mucosaen_US
dc.typeArticle
dspace.entity.typePublication

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