Effects of intermittent fasting on serum lipid levels, coagulation status and plasma homocysteine levels

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dc.contributor.authorAksungar, FB
dc.contributor.authorEren, A
dc.contributor.authorUre, S
dc.contributor.authorTeskin, O
dc.contributor.authorAtes, G
dc.date.accessioned2024-07-12T21:45:00Z
dc.date.available2024-07-12T21:45:00Z
dc.date.issued2005en_US
dc.departmentMaltepe Üniversitesien_US
dc.description.abstractBackground: During Ramadan, Muslims fast during the daylight hours for a month. The duration of restricted food and beverage intake is approximately 12 h/day which makes Ramadan a unique model of intermittent fasting. Many physiological and psychological changes are observed during Ramadan that are probably due to the changes in eating and sleeping patterns. Methods: Serum total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), prothrombin time, activated partial thromboplastin time (aPTT), plasma fibrinogen, D-dimer and homocysteine levels were measured in 24 healthy fasting volunteers (12 females, 12 males) aged 21-35 years. Venous blood samples were taken 1 week before Ramadan, on the 21st day of Ramadan and 20 days after Ramadan. Results: No significant changes were observed on serum total cholesterol, triglycerides and LDL levels. HDL levels were significantly elevated during Ramadan (p < 0.001) and 20 days after Ramadan (p < 0.05). Prothrombin time, aPTT, fibrinogen and D-dimer levels were in the physiologic limits in all samples but D-dimer levels were significantly low at the end of Ramadan in comparison to pre- and post-fasting levels (p < 0.001). Homocysteine levels, being still in reference ranges, were low during Ramadan (p < 0.05) and reached the pre-fasting levels after Ramadan. Conclusion: Our results demonstrate that intermittent fasting led to some beneficial changes in serum HDL and plasma homocysteine levels, and the coagulation status. These changes may be due to omitting at least one meal when the body was particularly metabolically active and possibly had a low blood viscosity level at the same time. We conclude that intermittent fasting may have beneficial effects on hemostatic risk markers for cardiovascular diseases. Copyright (C) 2005 S. Karger AG, Basel.en_US
dc.identifier.doi10.1159/000084739
dc.identifier.endpage82en_US
dc.identifier.issn0250-6807
dc.identifier.issn1421-9697
dc.identifier.issue2en_US
dc.identifier.pmid15802901en_US
dc.identifier.scopus2-s2.0-20444438742en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage77en_US
dc.identifier.urihttps://dx.doi.org/10.1159/000084739
dc.identifier.urihttps://hdl.handle.net/20.500.12415/7771
dc.identifier.volume49en_US
dc.identifier.wosWOS:000229475700002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKARGERen_US
dc.relation.ispartofANNALS OF NUTRITION AND METABOLISMen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKY00265
dc.subjecthomocysteineen_US
dc.subjectD-dimeren_US
dc.subjecthigh-density lipoproteinen_US
dc.subjectIslamic fastingen_US
dc.subjectRamadan, meal frequencyen_US
dc.subjectfasting, circadian variationen_US
dc.titleEffects of intermittent fasting on serum lipid levels, coagulation status and plasma homocysteine levelsen_US
dc.typeArticle
dspace.entity.typePublication

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